Breathnach A S, Robins E J, Nazzaro-Porro M, Passi S, Picardo M
Department of Anatomy and Cell Biology, St. Mary's Hospital Medical School, London, England.
Acta Derm Venereol Suppl (Stockh). 1989;143:62-6.
Azelaic acid has been shown to have a dose- and time-dependent inhibitory effect on both proliferation and cell viability of murine and human melanoma cells at a concentration of 10(-3) M and higher. It also has an inhibitory effect on DNA synthesis and plasminogen activator activity, and causes swelling and vacuolation of mitochondria. These effects have also been observed with other tumoral cells in culture-lymphoma and leukaemia derived cell lines, and human squamous cell carcinoma. Normal cells in culture are not generally affected by exposure to azelaic acid. Tissue culture experiments have confirmed the clinical activity and efficacy of azelaic acid, and biochemical conclusions as to its mode of action.
壬二酸已被证明，在浓度为10（-3）M及更高时，对鼠类和人类黑色素瘤细胞的增殖和细胞活力具有剂量和时间依赖性抑制作用。它对DNA合成和纤溶酶原激活剂活性也有抑制作用，并导致线粒体肿胀和空泡化。在培养的其他肿瘤细胞——淋巴瘤和白血病衍生细胞系以及人类鳞状细胞癌中也观察到了这些作用。培养中的正常细胞一般不受壬二酸暴露的影响。组织培养实验证实了壬二酸的临床活性和疗效，以及关于其作用方式的生化结论。
