Geier G, Hauschild T, Bauer R, Kreysel H W
Hautarzt. 1986 Mar;37(3):146-8.
Azelaic acid, a linear C9 dicarbonic acid, can effect a reduction in the growth of melanoma cells. This was shown in a comparison of two human melanoma cell cultures and cultured human skin fibroblasts. The cultures were observed for 24 days. The reduction in growth effected by azelaic acid showed significant differences concerning the dose-effect ratio in both melanoma cell lines observed. There was no inhibition of cell proliferation in the fibroblast cultures. Morphological and final trypan blue tests suggest that azelaic acid is not cytotoxic but cytostatic in a selective way.
壬二酸，一种直链C9二元羧酸，可使黑色素瘤细胞的生长减缓。这在两种人黑色素瘤细胞培养物与培养的人皮肤成纤维细胞的比较中得到了证实。对这些培养物进行了24天的观察。壬二酸所产生的生长减缓在观察到的两种黑色素瘤细胞系中显示出关于剂量效应比的显著差异。在成纤维细胞培养物中没有细胞增殖的抑制现象。形态学和最后的台盼蓝试验表明，壬二酸不是细胞毒性的，而是以一种选择性的方式具有细胞生长抑制作用。
