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[美沙拉嗪所致药物性肺炎三例]

[THREE CASES OF DRUG-INDUCED PNEUMONIA CAUSED BY MESALAZINE].

作者信息

Akiyama Norimichi, Yokomura Koshi, Nozue Tsuyoshi, Abe Takefumi, Matsui Takashi, Suda Takafumi

机构信息

Department of Respiratory Medicine, Seirei Mikatahara Hospital.

出版信息

Arerugi. 2015 Dec;64(10):1334-40. doi: 10.15036/arerugi.64.1334.

Abstract

We report three cases of drug-induced pneumonia caused by mesalazine. They were all diagnosed as ulcerative colitis and treated with mesalazine orally. Our three cases and literature review revealed that mesalazine-induced pneumonia resemble like eosinophilic pneumonia or organizing pneumonia and that have good prognosis with drug cessation or administration of corticosteroid. The patient of ulcerative colitis is increasing every year and it is anticipated that the patient with mesalazine-induced pneumonia may also increase. In the treatment of ulcerative colitis with mesalazine, we should pay attention with patient's cough or fever for early detection of drug-induced pneumonia.

摘要

我们报告了3例由美沙拉嗪引起的药物性肺炎病例。这些患者均被诊断为溃疡性结肠炎并接受口服美沙拉嗪治疗。我们的3例病例及文献回顾显示,美沙拉嗪诱发的肺炎类似嗜酸性粒细胞性肺炎或机化性肺炎,停用药物或给予糖皮质激素后预后良好。溃疡性结肠炎患者逐年增加,预计美沙拉嗪诱发肺炎的患者也可能增多。在用美沙拉嗪治疗溃疡性结肠炎时,我们应留意患者的咳嗽或发热情况,以便早期发现药物性肺炎。

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