Geronemus Roy, Du Ana, Yatskayer Margarita, Lynch Stephen, Krol Yevgeniy, Oresajo Christian
a Laser & Skin Surgery Center of New York , New York , NY , USA ;
b L'Oreal Research & Innovation , Clark , NJ , USA ;
J Cosmet Laser Ther. 2016 Jun;18(3):154-61. doi: 10.3109/14764172.2015.1112408. Epub 2016 Mar 31.
Photodamaged facial skin is characterized by fine lines and wrinkles, mottled pigmentation, and other changes.
To evaluate and compare the efficacy and tolerance of a home-use laser device when used alone or in combination with an antioxidant facial treatment for moderate photodamage.
This was a 49-subject, evaluator-blinded, split-face, randomized, single-center, 24-week, phase-2, study. In phase 1, all subjects were treated on one facial side with test products and a home-use laser device and the other side was treated with laser alone for 12 weeks, followed by a 2-week regression period during which they used only support materials. For phase 2, all subjects were divided into 2 independent treatment groups. For the next 10 weeks, subjects of first group treated the assigned facial side with test products and support materials and the other facial side with only support materials. Subjects in the second group treated their entire face with only support materials. Efficacy and tolerance were assessed by clinical grading, VISIA-CR imaging, and self-assessment questionnaires.
The combination of laser and test products improved all photodamage parameters evaluated.
The test products enhanced and prolonged clinical benefits obtained with the laser alone.
光损伤的面部皮肤表现为细纹、皱纹、色素沉着斑及其他变化。
评估和比较家用激光设备单独使用或与抗氧化面部治疗联合使用对中度光损伤的疗效和耐受性。
这是一项纳入49名受试者的、评估者盲法、半脸、随机、单中心、为期24周的2期研究。在第1阶段，所有受试者一侧面部用测试产品和家用激光设备进行治疗，另一侧仅用激光治疗12周，随后是为期2周的消退期，在此期间他们仅使用辅助材料。在第2阶段，所有受试者被分为2个独立的治疗组。在接下来的10周里，第一组受试者用测试产品和辅助材料治疗指定的面部一侧，另一侧仅用辅助材料治疗。第二组受试者整个面部仅用辅助材料治疗。通过临床分级、VISIA-CR成像和自我评估问卷评估疗效和耐受性。
激光与测试产品联合使用改善了所有评估的光损伤参数。
测试产品增强并延长了单独使用激光所获得的临床益处。
