一项随机、研究者盲法、半脸、对照试验，评估含蓝莓提取物和羟丙基四氢吡喃三醇并联合微聚焦超声的局部用产品的抗衰功效及满意度。
A Randomized, Investigator-Blinded, Split-Face, Controlled Trial Evaluating the Efficacy and Satisfaction of a Topical Product Containing Blueberry Extract and Pro-Xylane Combined With Micro-Focused Ultrasound for Anti-aging.
作者信息
Jiang Xiaoling, Peng Shiqi, Chen Ying, Nan Yuqing, Song Weimin
机构信息
Hang Zhou YesSkin Hospital, Hangzhou, Zhejiang, China.
出版信息
J Cosmet Dermatol. 2025 Jul;24(7):e70281. doi: 10.1111/jocd.70281.
BACKGROUND
Micro-focused ultrasound (MFUS) has been effective in treating skin aging, which manifests as skin thinning, reduced elasticity, wrinkling, etc. AIMS: This study aims to evaluate the efficacy and satisfaction of combining a product containing blueberry extract and Pro-xylane (A.G.E. cream) with MFUS in antiaging effects in the Chinese population.
METHODS
In this randomized, investigator-blinded, controlled trial, patients aged 18-65 with skin roughness, sagging, laxity, or fine lines/wrinkles were enrolled. After MFUS, one side of patients' faces was randomly assigned to apply the A.G.E. cream and the other side with the standard moisturizer. Patients were followed up for 180 days. The primary endpoint was the Global Aesthetic Improvement Scale (GAIS). Secondary endpoints included percentage changes from baseline in fine lines, skin elasticity, dermal thickness, and transepidermal water loss. Patient and dermatologist satisfaction was evaluated using a questionnaire.
RESULTS
A total of 50 patients were included in the study, with 49 (98%) being female. The mean ± SD age was 33.7 ± 6.4 years. For the primary endpoint, the intervention side demonstrated significant improvement in GAIS compared to the control side on Day 90 (p < 0.001). For secondary endpoints, the A.G.E. cream use after MFUS significantly improved skin elasticity at the cheeks and mouth corners on multiple follow-up days and improved fine lines at the mouth corners on Day 180. Patients and dermatologists reported higher satisfaction levels with the aesthetic outcomes of the intervention side.
CONCLUSIONS
The application of the A.G.E. cream following MFUS treatment improved skin elasticity, dermal thickness, fine lines, and patient/dermatologist satisfaction.
TRIAL REGISTRATION
ClinicalTrials.gov identifier: NCT05748470.
背景
微聚焦超声（MFUS）在治疗皮肤老化方面已显示出效果，皮肤老化表现为皮肤变薄、弹性降低、出现皱纹等。目的：本研究旨在评估含有蓝莓提取物和玻色因（A.G.E. 面霜）的产品与MFUS联合使用对中国人群抗老化效果的有效性和满意度。
方法
在这项随机、研究者盲法、对照试验中，纳入了年龄在18 - 65岁、有皮肤粗糙、松弛、下垂或细纹/皱纹的患者。MFUS治疗后，患者面部一侧随机分配使用A.G.E. 面霜，另一侧使用标准保湿霜。对患者进行180天的随访。主要终点是全球美学改善量表（GAIS）。次要终点包括细纹、皮肤弹性、真皮厚度和经表皮水分流失相对于基线的百分比变化。使用问卷评估患者和皮肤科医生的满意度。
结果
本研究共纳入50例患者，其中49例（98%）为女性。平均年龄±标准差为33.7±6.4岁。对于主要终点，在第90天时，干预侧的GAIS相较于对照侧有显著改善（p < 0.001）。对于次要终点，MFUS后使用A.G.E. 面霜在多个随访日显著改善了脸颊和嘴角的皮肤弹性，并在第180天时改善了嘴角的细纹。患者和皮肤科医生对干预侧的美学效果满意度更高。
结论
MFUS治疗后应用A.G.E. 面霜可改善皮肤弹性、真皮厚度、细纹，并提高患者/皮肤科医生的满意度。
试验注册
ClinicalTrials.gov标识符：NCT05748470。
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