Shen Qinpeng, Xu Xingmeng, Liu Chunbo, Zhao Wei, Xiang Nengjun, Chen Yongkuan, Miao Mingming, Liu Zhihua, Yang Guangyu
a Key Laboratory of Tobacco Chemistry of Yunnan Province , China Tobacco Yunnan Industrial Co., Ltd , Kunming , P.R. China.
b School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Nature Products , Kunming Medical University , Kunming , P.R. China.
Nat Prod Res. 2016 Nov;30(22):2545-2550. doi: 10.1080/14786419.2015.1120729. Epub 2016 Jan 4.
Two new sesquiterpenes, nicotianasesterpenes A and B (1 and 2), together with five known sesquiterpenes (3-7) were isolated from the leaves of Nicotiana tabacum. Their structures were determined mainly by spectroscopic methods, including extensive 1D- and 2D-NMR techniques. The anti-tobacco mosaic virus (anti-TMV) activities of compounds 1-7 were evaluated. The results revealed that compound 1 exhibited high anti-TMV activities with inhibition rates of 33.6%. This rate is high than that of positive control. The other compounds also showed potential activities with inhibition rates in the range of 18.8-28.4%, respectively.
从烟草叶片中分离出两种新的倍半萜类化合物，烟草酯萜A和B（1和2），以及五种已知的倍半萜类化合物（3 - 7）。它们的结构主要通过光谱方法确定，包括广泛的一维和二维核磁共振技术。对化合物1 - 7的抗烟草花叶病毒（抗TMV）活性进行了评估。结果表明，化合物1表现出高抗TMV活性，抑制率为33.6%。该抑制率高于阳性对照。其他化合物也分别表现出18.8 - 28.4%范围内的潜在活性。
