Çelebisoy Neşe, Gökçay Figen, Karahan Ceyda, Bilgen Cem, Kirazlı Tayfun, Karapolat Hale, Köse Timur
Department of Neurology, Ege University Medical School, Bornova, İzmir, 35100, Turkey.
Department of Otorhinolaryngology, Head and Neck Surgery, Ege University Medical School, Bornova, İzmir, 35100, Turkey.
Eur Arch Otorhinolaryngol. 2016 Oct;273(10):2947-51. doi: 10.1007/s00405-015-3874-4. Epub 2016 Jan 4.
The aim of this study is to check the efficacy of acetazolamide in the prophylaxis of vestibular migraine (VM). Treatment options in VM are mainly based on migraine guidelines. We tried to assess the efficacy of acetazolamide in these patients depending on clinical similarities with episodic ataxia type 2 and familial hemiplegic migraine responding to the drug. This is a retrospective cohort study. Among 50 patients with VM and prescribed acetazolamide 500 mg/day, 39 patients were studied as five had been lost on follow-up and six had stopped taking the drug due to side effects. Vertigo and headache frequency determined by number of attacks per month, and the severity determined by visual analog scales measured in centimeters from 0 to 10 were collected from the records. Initial reported figures for frequency and severity were compared with the results gathered after 3 months of treatment. The results were compared. Acetazolamide was effective in reducing both the frequency and severity of vertigo and headache attacks and this effect was more prominent for vertigo frequency and severity.
本研究的目的是检验乙酰唑胺预防前庭性偏头痛（VM）的疗效。VM的治疗方案主要基于偏头痛指南。我们试图根据与发作性共济失调2型和对该药物有反应的家族性偏瘫性偏头痛的临床相似性，评估乙酰唑胺对这些患者的疗效。这是一项回顾性队列研究。在50例VM患者中，每天服用500毫克乙酰唑胺，其中39例患者被纳入研究，5例失访，6例因副作用停药。从记录中收集每月发作次数确定的眩晕和头痛频率，以及以0至10厘米视觉模拟量表测量的严重程度。将最初报告的频率和严重程度数据与治疗3个月后收集的结果进行比较。对结果进行比较。乙酰唑胺在降低眩晕和头痛发作的频率和严重程度方面均有效，且对眩晕频率和严重程度的效果更为显著。
