抑郁症患者的炎症标志物与自杀未遂：综述
Inflammatory markers and suicidal attempts in depressed patients: A review.
作者信息
Marini Stefano, Vellante Federica, Matarazzo Ilaria, De Berardis Domenico, Serroni Nicola, Gianfelice Daniela, Olivieri Luigi, Di Renzo Fulvia, Di Marco Anna, Fornaro Michele, Orsolini Laura, Valchera Alessandro, Iasevoli Felice, Mazza Monica, Perna Giampaolo, Martinotti Giovanni, Di Giannantonio Massimo
机构信息
Department of Neurosciences and Imaging, Chair of Psychiatry, University "G. D'Annunzio", Chieti, Italy
Department of Neurosciences and Imaging, Chair of Psychiatry, University "G. D'Annunzio", Chieti, Italy.
出版信息
Int J Immunopathol Pharmacol. 2016 Dec;29(4):583-594. doi: 10.1177/0394632015623793. Epub 2016 Jan 4.
Abstract
Major depressive disorder is a chronic and invalidating psychiatric illness and is associated with a greater risk of suicidal behaviors. In recent decades many data have supported a biological link between depressive states and inflammation. Pro-inflammatory cytokines have been found to rise, first of all TNF-α and IL-6. Suicidal behaviors have been consistently associated with increased levels of IL-6 and decreased levels of IL-2. The aim of this review is to investigate the relationship between inflammatory markers in depressed patients with or without suicidal attempts compared to healthy controls.
摘要
重度抑郁症是一种慢性致残性精神疾病，与更高的自杀行为风险相关。近几十年来，许多数据支持抑郁状态与炎症之间存在生物学联系。已发现促炎细胞因子会升高，首先是肿瘤坏死因子-α和白细胞介素-6。自杀行为一直与白细胞介素-6水平升高和白细胞介素-2水平降低有关。本综述的目的是研究与健康对照相比，有或无自杀未遂的抑郁症患者炎症标志物之间的关系。
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