作为氟喹诺酮类药物肌毒性效应原因的代谢作用
Metabolic effects as a cause of myotoxic effects of fluoroquinolones.
作者信息
Metterlein Thomas, Schuster Frank, Hager Martin, Roewer Norbert, Anetseder Martin
机构信息
Department of Anesthesiology, University Hospital Regensburg, Regensburg, Germany.
Department of Anesthesiology, Hospital Wuerzburg, Wuerzburg, Germany.
出版信息
Indian J Pharmacol. 2015 Nov-Dec;47(6):616-9. doi: 10.4103/0253-7613.169571.
OBJECTIVES
To investigate if fluoroquinolones (FQs) influence skeletal muscle metabolism of healthy and malignant hyperthermia susceptible (MHS) pigs.
MATERIALS AND METHODS
After approval from of the Animal Care Committee, 10 MHS pigs, and 6 MHS pigs were anesthetized with hemodynamic and systemic metabolic monitoring. Microdialysis catheters were placed intramuscularly. After equilibration, levofloxacin and ciprofloxacin were injected as a rapid bolus and continuous infusions. Lactate was measured in the dialysate and statistically analyzed was done (Wilcoxon-test; U-test; P < 0.05).
RESULTS
There were no differences in age, weight, and baseline lactate levels between the groups. Both applications of levofloxacin- and ciprofloxacin-induced an increase of local lactate levels in healthy and MHS pigs. No difference between the two groups was observed.
CONCLUSION
FQs influence skeletal muscle metabolism. Myotoxic effects of FQs can, therefore, be explained by an influence on the cellular energy balance.
目的
研究氟喹诺酮类药物（FQs）是否影响健康猪和恶性高热易感（MHS）猪的骨骼肌代谢。
材料与方法
经动物护理委员会批准，对10头MHS猪和6头健康猪进行麻醉，并进行血流动力学和全身代谢监测。将微透析导管肌肉内植入。平衡后，快速推注并持续输注左氧氟沙星和环丙沙星。测定透析液中的乳酸含量并进行统计学分析（Wilcoxon检验；U检验；P<0.05）。
结果
两组之间在年龄、体重和基线乳酸水平方面无差异。左氧氟沙星和环丙沙星的应用均导致健康猪和MHS猪局部乳酸水平升高。两组之间未观察到差异。
结论
FQs影响骨骼肌代谢。因此，FQs的肌毒性作用可通过对细胞能量平衡的影响来解释。
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