Garg Yashika, Gore Rajeshwari, Jain Sourabh, Kumar Arun
Department of Pharmacology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
Department of Dermatology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
Indian J Pharmacol. 2015 Nov-Dec;47(6):682-4. doi: 10.4103/0253-7613.169575.
Tuberculosis is a common infectious disease in developing countries. Isoniazid is established the first-line antitubercular drug and an essential component of all antitubercular regimens. Erythroderma caused by isoniazid is an uncommon but serious adverse drug reaction. We report here a case of a 63-year-old female patient who presented with generalized redness and scaling with itching after 8 weeks of antitubercular treatment (ATT). ATT was stopped immediately, and antihistaminics were started. The patient improved over a period of 2 weeks. On sequential rechallenge, she developed similar lesions all over the body with isoniazid, hence confirming the diagnosis of isoniazid-induced erythroderma.
结核病是发展中国家的一种常见传染病。异烟肼是公认的一线抗结核药物，也是所有抗结核治疗方案的重要组成部分。异烟肼引起的红皮病是一种罕见但严重的药物不良反应。我们在此报告一例63岁女性患者，在接受抗结核治疗（ATT）8周后出现全身发红、脱屑伴瘙痒。立即停用ATT，并开始使用抗组胺药。患者在2周内病情好转。在后续的再次激发试验中，她使用异烟肼后全身出现类似皮疹，从而确诊为异烟肼所致红皮病。
