Yousuf Tariq, Brinton Taylor, Kramer Jason, Khan Basharath, Ziffra Jeffrey, Villines Dana, Shah Poorvi, Hanif Tabassum
Department of Internal Medicine, Advocate Christ Medical Center, Oak Lawn, IL.
Rosalind Franklin University of Medicine and Science, Chicago, IL.
Ochsner J. 2015 Winter;15(4):418-22.
Respiratory depression is a common adverse effect of benzodiazepine administration to patients with severe alcoholic withdrawal. This study was conducted to assess the value of end tidal carbon dioxide (ETCO2) levels compared to partial pressure of arterial carbon dioxide (PaCO2) levels in monitoring respiratory depression secondary to benzodiazepine treatment in patients with severe alcohol withdrawal.
We retrospectively analyzed 36 patients admitted to the intensive care unit for severe alcohol withdrawal who had been administered sedative agents.
We observed a statistically significant correlation between PaCO2 and ETCO2 at time 1 (r=0.74, P<0.01) and time 3 (r=0.52, P=0.02) but not at time 2 (r=0.22, P=0.31).
Our study confirms a positive correlation between PaCO2 and ETCO2 levels in patients experiencing severe alcohol withdrawal.
呼吸抑制是苯二氮䓬类药物用于严重酒精戒断患者时常见的不良反应。本研究旨在评估在监测严重酒精戒断患者因苯二氮䓬类药物治疗继发的呼吸抑制时，呼气末二氧化碳（ETCO2）水平与动脉血二氧化碳分压（PaCO2）水平相比的价值。
我们回顾性分析了36例因严重酒精戒断入住重症监护病房且已接受镇静剂治疗的患者。
我们观察到在时间1（r = 0.74，P < 0.01）和时间3（r = 0.52，P = 0.02）时，PaCO2与ETCO2之间存在统计学显著相关性，但在时间2时不存在（r = 0.22，P = 0.31）。
我们的研究证实了严重酒精戒断患者的PaCO2与ETCO2水平之间存在正相关。
