在ST段抬高型心肌梗死发病伊始，冠状动脉内血小板衍生生长因子和基质金属蛋白酶-9的体内血浆水平较高。
In-Vivo Higher Plasma Levels of Platelet-Derived Growth Factor and Matrix Metalloproteinase-9 in Coronary Artery at the Very Onset of Myocardial Infarction with ST-Segment Elevation.
作者信息
Koizumi Tomomi, Komiyama Nobuyuki, Nishimura Shigeyuki
机构信息
Department of Cardiovascular Medicine, Saitama International Medical Center, Saitama Medical University, Hidaka, Saitama, Japan.
出版信息
Ann Vasc Dis. 2015;8(4):297-301. doi: 10.3400/avd.oa.15-00057. Epub 2015 Sep 4.
OBJECTIVE
Platelet-derived growth factor (PDGF) induces matrix metalloproteinase (MMP), which is regarded as a biomarker of plaque rupture or vulnerability. The aim of this study is to investigate those interactions in human coronary arteries at the onset of ST-segment elevation myocardial infarction (STEMI).
METHODS
Thirty-two patients with STEMI who underwent primary percutaneous coronary intervention (PCI) were enrolled in this study. Plasma levels of PDGF-BB and MMP-9 were measured from infarct-related artery (IRA) and from femoral artery (FA) during PCI.
RESULTS
Plasma levels of PDGF-BB and MMP-9 in the IRA were significantly higher than those in the FA (PDGF-BB: median 3130 pg/ml, IQR (interquartile range): 2020 to 4375 pg/ml vs. median 2605 pg/ml, IQR: 1305 to 3290 pg/ml, p <0.01, MMP-9: median 49 ng/ml, IQR: 35 to 100 ng/ml vs. median 42 ng/ml, IQR: 27 to 78 ng/ml, p = 0.04, IRA and FA, respectively).
CONCLUSIONS
This in vivo study demonstrated that PDGF-BB with MMP-9 seems to play a role in coronary plaque instability in acute phase of STEMI.
目的
血小板衍生生长因子（PDGF）可诱导基质金属蛋白酶（MMP），而基质金属蛋白酶被视为斑块破裂或易损性的生物标志物。本研究旨在探讨ST段抬高型心肌梗死（STEMI）发病时人类冠状动脉中的这些相互作用。
方法
本研究纳入了32例行直接经皮冠状动脉介入治疗（PCI）的STEMI患者。在PCI期间，测量梗死相关动脉（IRA）和股动脉（FA）中的PDGF-BB和MMP-9血浆水平。
结果
IRA中的PDGF-BB和MMP-9血浆水平显著高于FA中的水平（PDGF-BB：中位数3130 pg/ml，四分位间距（IQR）：2020至4375 pg/ml，而FA中中位数为2,605 pg/ml，IQR：1305至3290 pg/ml，p<0.01；MMP-9：中位数49 ng/ml，IQR：35至100 ng/ml，而FA中中位数为42 ng/ml，IQR：27至78 ng/ml，p = 0.04，分别为IRA和FA）。
结论
这项体内研究表明，PDGF-BB与MMP-9似乎在STEMI急性期冠状动脉斑块不稳定中起作用。
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