Pang Sisi, Tao Zhengxian, Min Xiaoyan, Zhou Chuanwei, Pan Dijia, Cao Zhen, Wang Xiangming
Department of Geriatric Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Cardiol Res Pract. 2020 Sep 10;2020:3602608. doi: 10.1155/2020/3602608. eCollection 2020.
The expression of the platelet-derived growth factor (PDGF), angiopoietin-1 (Ang-1) in patients with coronary artery disease of different studies was inconsistent. This study was to investigate the expression of the PDGF and Ang-1 in peripheral blood and coronary artery in patients with acute coronary syndrome (ACS) and the relationship between the expression of the PDGF and Ang-1 and the severity of coronary artery disease.
A total of 81 patients with acute coronary syndrome undergoing coronary angiography were enrolled from September 2012 to December 2013. Patients with ACS included 61 patients with acute myocardial infarction (AMI group) and 20 patients with unstable angina pectoris (UAP group). The 29 patients who were hospitalized for chest pain undergoing coronary angiography without stenosis and with TIMI level 3 blood flow were selected as the control group. During coronary arteriography (CAG) or percutaneous coronary intervention (PCI), blood in the peripheral artery and in the local coronary artery was collected from all the patients. Serum PDGF and Ang-1 levels were measured by ELISA. We calculated the Gensini score of each patient with CHD according to the result of CAG. Patients with ACS were followed up, and the major adverse cardiovascular and cerebrovascular adverse events were recorded.
In peripheral blood, the concentration of the PDGF was significantly elevated in the ACS group than that of the control group. The level of the PDGF in the AMI group was significantly higher than that in the UAP group. In coronary artery blood, the level of the PDGF in the ACS group was significantly higher than that of the UAP group. There was no significant difference in the concentration of Ang-1 in peripheral blood between patients with coronary heart disease and the control group. The concentration of Ang-1 in the coronary artery was significantly lower than that in peripheral blood. The coronary Ang-1 concentrations in the ACS group were significantly higher than those in the UAP group. The concentrations of the PDGF and Ang-1 in peripheral and coronary artery blood were positively correlated with the severity of coronary lesions. Patients with MACCE had higher PDGF and Ang-1 levels in the coronary sinus.
The serum PDGF concentration in patients with acute coronary syndrome was significantly increased, especially in the local coronary artery. The serum Ang-1 in the coronary artery was significantly increased in patients with acute myocardial infarction and was related to the degree of coronary artery stenosis. Coronary sinus PDGF and Ang-1 levels can reflect the severity of lesions in patients with acute coronary syndrome.
不同研究中血小板衍生生长因子（PDGF）、血管生成素-1（Ang-1）在冠心病患者中的表达情况不一致。本研究旨在探讨急性冠脉综合征（ACS）患者外周血及冠状动脉中PDGF和Ang-1的表达情况，以及PDGF和Ang-1的表达与冠状动脉疾病严重程度之间的关系。
选取2012年9月至2013年12月期间81例行冠状动脉造影的急性冠脉综合征患者。ACS患者包括61例急性心肌梗死患者（AMI组）和20例不稳定型心绞痛患者（UAP组）。选取29例因胸痛住院行冠状动脉造影无狭窄且TIMI血流3级的患者作为对照组。在冠状动脉造影（CAG）或经皮冠状动脉介入治疗（PCI）过程中，采集所有患者外周动脉血及局部冠状动脉血。采用酶联免疫吸附测定法（ELISA）检测血清PDGF和Ang-1水平。根据CAG结果计算每位冠心病患者的Gensini评分。对ACS患者进行随访，记录主要不良心血管和脑血管不良事件。
外周血中，ACS组PDGF浓度显著高于对照组。AMI组PDGF水平显著高于UAP组。冠状动脉血中，ACS组PDGF水平显著高于UAP组。冠心病患者与对照组外周血中Ang-1浓度无显著差异。冠状动脉中Ang-1浓度显著低于外周血。ACS组冠状动脉Ang-1浓度显著高于UAP组。外周血和冠状动脉血中PDGF和Ang-1浓度与冠状动脉病变严重程度呈正相关。发生主要不良心血管和脑血管事件的患者冠状动脉窦中PDGF和Ang-1水平较高。
急性冠脉综合征患者血清PDGF浓度显著升高，尤其是局部冠状动脉。急性心肌梗死患者冠状动脉血清Ang-1显著升高，且与冠状动脉狭窄程度有关。冠状动脉窦PDGF和Ang-1水平可反映急性冠脉综合征患者病变的严重程度。
