Thoracic Clinical College, Tianjin Medical University, Tianjin, P.R. China.
Department of Cardiology, Tianjin Chest Hospital, Tianjin, P.R. China.
Ann Med. 2023 Dec;55(1):1047-1057. doi: 10.1080/07853890.2023.2176542.
The value of plasma Platelet-Derived Growth Factor (PDGF) as a biomarker in predicting major adverse cardiovascular events (MACEs) in patients with acute non-ST-segment elevation myocardial infarction (NSTEMI) remains unclear.
A total of 242 patients with NSTEMI were enrolled in this observational cohort study. The correlation between PDGF and MACEs was evaluated during a five-year follow-up. Kaplan-Meier survival analysis with Cox proportional-hazards regression was used to identify predictive values of PDGF.
The mean follow-up of NSTEMI patients was 1334 days. It was found that as the PDGF level increased, a significant uptrend in the incidence of MACEs and all-cause death, including the MACEs of 30 days, 180 days, 1 year, 5 years and the death of 1 year and 5 years (All Log-rank < .05). Subgroup analysis further showed that PDGF had better predictive value for patients with age >65 years, GRACE score ≥140 and platelet count (PLT) >200 × 10/L.
PDGF levels can predict short-term and long-term MACEs in NSTEMI patients after discharge, especially for patients with older age, higher GRACE score and baseline PLT > 200 × 10/L.Key messagesPDGF is a risk factor for short- and long-term MACEs in patients with STEMI.PDGF has a better prognostic value in patients with older age and PLT > 200 × 10/L.Baseline plasma PDGF levels were positively correlated with GRACE score.
血浆血小板衍生生长因子（PDGF）作为急性非 ST 段抬高型心肌梗死（NSTEMI）患者预测主要不良心血管事件（MACEs）的生物标志物的价值尚不清楚。
这项观察性队列研究共纳入 242 例 NSTEMI 患者。在 5 年随访期间评估 PDGF 与 MACEs 的相关性。采用 Kaplan-Meier 生存分析和 Cox 比例风险回归来确定 PDGF 的预测价值。
NSTEMI 患者的平均随访时间为 1334 天。结果发现，随着 PDGF 水平的升高，MACEs 和全因死亡的发生率呈显著上升趋势，包括 30 天、180 天、1 年、5 年的 MACEs 和 1 年和 5 年的死亡（所有 Log-rank < .05）。亚组分析进一步表明，PDGF 对年龄>65 岁、GRACE 评分≥140 和血小板计数（PLT）>200×10/L 的患者具有更好的预测价值。
PDGF 水平可预测 NSTEMI 患者出院后短期和长期的 MACEs，尤其是年龄较大、GRACE 评分较高和基线 PLT>200×10/L 的患者。
PDGF 是 STEMI 患者短期和长期 MACEs 的危险因素。PDGF 在年龄较大和 PLT>200×10/L 的患者中具有更好的预后价值。基线血浆 PDGF 水平与 GRACE 评分呈正相关。
