Tang Nikki, Maloney Mary E, Clark Ashlynne H, Jellinek Nathaniel J
*Department of Dermatology, Mt Sinai St. Lukes-Roosevelt and Beth Israel Hospital Center, New York, New York; †Division of Dermatology, University of Massachusetts Medical School, Worcester, Massachusetts; ‡Dermatology Professionals, Inc., East Greenwich, Rhode Island; §Department of Dermatology, The Warren Alpert Medical School at Brown University, Providence, Rhode Island.
Dermatol Surg. 2016 Jan;42 Suppl 1:S8-S17. doi: 10.1097/DSS.0000000000000521.
Squamous cell carcinoma (SCC) of the nail is infrequently reported in the medical literature and its causes are poorly understood. Studies have shown strong associations with immunosuppression, tobacco use, toxin/radiation exposure, and trauma. Common treatments include Mohs surgery and digital amputation.
Review a series of nail SCCs treated at 2 institutions. Outcomes evaluated included rates of recurrence and disease progression/metastasis after treatment.
A retrospective review of patients treated between 2005 and 2008. Medical record review and phone call follow-up using a standardized questionnaire were used.
Forty-two tumors were identified in 34 patients. Twenty-seven patients were male (79% CI, 62%-91%) and most tumors were located on the fingernails (39/42; 91% CI, 81%-99%). Twenty-four of 39 tumors (62% CI, 45%-77%) were on the nondominant hand. The middle third finger was the most frequent digit affected (16/42). Common symptoms reported were nail dystrophy (31/42; 74% CI, 58%-86%), followed by onycholysis (22/42; 52% CI, 36%-68%). Most tumors (35/42; 83% CI, 69%-93%) were treated with Mohs surgery.
Nail SCC is found nearly exclusively in adults and predominantly in men. There are multiple effective treatment possibilities including Mohs surgery, distal digital amputation, and early evidence suggesting radiotherapy.
甲鳞状细胞癌（SCC）在医学文献中的报道较少，其病因也鲜为人知。研究表明，它与免疫抑制、吸烟、毒素/辐射暴露及创伤密切相关。常见的治疗方法包括莫氏手术和手指截肢术。
回顾在两家机构治疗的一系列甲SCC病例。评估的结果包括治疗后的复发率及疾病进展/转移率。
对2005年至2008年期间接受治疗的患者进行回顾性研究。采用病历回顾及使用标准化问卷进行电话随访。
在34例患者中发现了42个肿瘤。27例为男性（79%可信区间，62%-91%），大多数肿瘤位于手指甲（39/42；91%可信区间，81%-99%）。39个肿瘤中有24个（62%可信区间，45%-77%）位于非优势手。中指是最常受累的手指（16/42）。报告的常见症状为甲营养不良（31/42；74%可信区间，58%-86%），其次是甲剥离（22/42；52%可信区间，36%-68%）。大多数肿瘤（35/42；83%可信区间，69%-93%）采用莫氏手术治疗。
甲SCC几乎仅见于成年人，且以男性为主。有多种有效的治疗方法，包括莫氏手术、手指远端截肢术，以及早期有证据表明放射治疗也有效。
