Nordlind K, Mutt V, Sundström E
Department of Dermatology, Karolinska Hospital, Stockholm, Sweden.
Drug Des Deliv. 1989 Jun;4(4):273-8.
Neuropeptides and monoamines are found in tissues where immune reactions are initiated such as the skin, gut and respiratory tract. In these tissues they might influence lymphocyte activation in inflammatory diseases. Both stimulatory and inhibitory effects have been described. The inhibitory effects may prove to be of pathophysiological and pharmacological importance. Studies both in vitro and in vivo showing that various neuropeptides and monoamines may inhibit reactions such as T lymphocyte proliferation, Blymphocyte proliferation and antibody synthesis, lymphocyte migration and cytotoxicity, are reviewed.
神经肽和单胺存在于引发免疫反应的组织中，如皮肤、肠道和呼吸道。在这些组织中，它们可能会影响炎症性疾病中的淋巴细胞激活。已经描述了刺激作用和抑制作用。抑制作用可能在病理生理学和药理学上具有重要意义。本文综述了体外和体内研究，这些研究表明各种神经肽和单胺可能会抑制诸如T淋巴细胞增殖、B淋巴细胞增殖和抗体合成、淋巴细胞迁移和细胞毒性等反应。
