FOXC2在胰腺导管腺癌中上调，并促进癌细胞的生长和迁移。
FOXC2 is up-regulated in pancreatic ductal adenocarcinoma and promotes the growth and migration of cancer cells.
作者信息
Cui Lei, Dang Shengchun, Qu Jianguo, Mao Zhengfa, Wang Xuqing, Zhang Jianxin, Chen Jixiang
机构信息
General Surgery Department, Affiliated Hospital, Jiangsu University, 438 Jie-Fang Rd., Zhenjiang, 212003, Jiangsu Province, People's Republic of China.
出版信息
Tumour Biol. 2016 Jul;37(7):8579-85. doi: 10.1007/s13277-015-4607-4. Epub 2016 Jan 6.
The transcriptional factor Forkhead box protein C2 (FOXC2) was recently demonstrated to be up-regulated in various cancer types. However, its expression profile and the biological functions in pancreatic cancer remain unknown. In this study, we examined the expression pattern of FOXC2 in pancreatic ductal adenocarcinoma (PDAC) tissues and investigated the functions of FOXC2 in the progression of PDAC. It was found that the expression of FOXC2 was up-regulated in PDAC samples. Forced expression of FOXC2 promoted the growth and migration of the PDAC cells, while knocking down the expression of FOXC2 inhibited the growth and migration of the PDAC cells. Moreover, FOXC2 was found to interact with beta-catenin and promote cell growth by activating beta-catenin/TCF signaling. Taken together, this study demonstrated the oncogenic roles of FOXC2 in PDAC, and FOXC2 might be a therapeutic target for PDAC.
转录因子叉头框蛋白C2（FOXC2）最近被证明在多种癌症类型中上调。然而，其在胰腺癌中的表达谱和生物学功能仍不清楚。在本研究中，我们检测了FOXC2在胰腺导管腺癌（PDAC）组织中的表达模式，并研究了FOXC2在PDAC进展中的功能。发现FOXC2在PDAC样本中表达上调。FOXC2的强制表达促进了PDAC细胞的生长和迁移，而敲低FOXC2的表达则抑制了PDAC细胞的生长和迁移。此外，发现FOXC2与β-连环蛋白相互作用，并通过激活β-连环蛋白/TCF信号促进细胞生长。综上所述，本研究证明了FOXC2在PDAC中的致癌作用，并且FOXC2可能是PDAC的一个治疗靶点。
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