Zhan Jianchao, Morsi Yosry, Ei-Hamshary Hany, Al-Deyab Salem S, Mo Xiumei
a Chemical Engineering and Biotechnology , College of Chemistry, Donghua University , Shanghai , P.R. China.
b College of Materials and Textile Engineering , Jiaxing University , Zhejiang Province , P.R. China.
J Biomater Sci Polym Ed. 2016;27(5):385-402. doi: 10.1080/09205063.2015.1133156. Epub 2016 Jan 22.
Electrospun gelatin(Gel) nanofibers scaffold has such defects as poor mechanical property and quick degradation due to high solubility. In this study, the in situ cross-linked electrospinning technique was used for the production of gelatin nanofibers. Deionized water was chosen as the spinning solvent and graphite oxide (GO) was chosen as the enhancer. The morphological structure, porosity, thermal property, moisture absorption, and moisture retention performance, hydrolysis resistance, mechanical property, and biocompatibility of the produced nanofibers were investigated. Compared with in situ cross-linked gelatin nanofibers scaffold, in situ cross-linked Gel-GO nanofibers scaffold has the following features: (1) the hydrophilicity, moisture absorption, and moisture retention performance slightly reduce, while the hydrolysis resistance is improved; (2) the breaking strength, breaking elongation, and Young's modulus are significantly improved; (3) the porosity slightly reduces while the biocompatibility considerably increases. The in situ cross-linked Gel-GO nanofibers scaffold is likely to be applied in such fields as drug delivery and scaffold for skin tissue engineering.
静电纺丝明胶（Gel）纳米纤维支架存在力学性能差和因高溶解性导致快速降解等缺陷。在本研究中，采用原位交联静电纺丝技术制备明胶纳米纤维。选择去离子水作为纺丝溶剂，选择氧化石墨烯（GO）作为增强剂。对所制备纳米纤维的形态结构、孔隙率、热性能、吸湿和保湿性能、耐水解性、力学性能及生物相容性进行了研究。与原位交联明胶纳米纤维支架相比，原位交联Gel-GO纳米纤维支架具有以下特点：（1）亲水性、吸湿和保湿性能略有降低，而耐水解性得到提高；（2）断裂强度、断裂伸长率和杨氏模量显著提高；（3）孔隙率略有降低，而生物相容性显著增加。原位交联Gel-GO纳米纤维支架有望应用于药物递送和皮肤组织工程支架等领域。
