Loerup Lise, Pullon Rebecca M, Birks Jacqueline, Fleming Susannah, Mackillop Lucy H, Watkinson Peter J
Department of Engineering Science, University of Oxford, Oxford, UK.
Centre for Statistics in Medicine, University of Oxford, Oxford, UK.
BMJ Open. 2016 Jan 5;6(1):e008769. doi: 10.1136/bmjopen-2015-008769.
Vital signs (blood pressure, heart rate, temperature, oxygen saturation and respiratory rate) are thought to undergo changes during and immediately after pregnancy. However, these physiological changes are not taken into account in the normal ranges, which themselves are not evidence-based, used in routine and acute care monitoring. We aim to synthesise the existing evidence base for changes in vital signs during pregnancy, in order to derive new centile charts for each stage of pregnancy and the immediate postpartum period.
We will search the MEDLINE, EMBASE and CINAHL databases from their inception to April 2015 for vital signs from pregnant, intrapartum or postpartum women who were recruited as 'healthy'. Assessment of bias will be conducted using a predefined set of independently agreed methodological criteria, which assigns an overall quality score to each study. We will record whether the vital sign measurements were made with measurement devices validated for use in pregnancy and in a standard posture. We will use regression methods to construct centile charts of vital signs across pregnancy and the immediate postpartum period for each vital sign. We will compare existing reference ranges to those derived from our centile charts.
The systematic review will be published in a peer-reviewed journal and disseminated electronically and in print.
CRD42014009673.
生命体征（血压、心率、体温、血氧饱和度和呼吸频率）被认为在孕期及产后即刻会发生变化。然而，常规和急症护理监测中使用的正常范围并未考虑这些生理变化，而且这些范围本身也并非基于证据。我们旨在综合孕期生命体征变化的现有证据基础，以便为孕期各阶段及产后即刻得出新的百分位数图表。
我们将检索MEDLINE、EMBASE和CINAHL数据库，从建库至2015年4月，查找被招募为“健康”的孕妇、分娩期妇女或产后妇女的生命体征。将使用一组预先定义的、经独立商定的方法学标准进行偏倚评估，该标准会为每项研究赋予一个总体质量评分。我们将记录生命体征测量是否使用了经验证可用于孕期且姿势标准的测量设备。我们将使用回归方法为每个生命体征构建孕期及产后即刻的生命体征百分位数图表。我们将把现有的参考范围与从我们的百分位数图表得出的范围进行比较。
系统评价将发表在同行评审期刊上，并以电子和印刷形式传播。
PROSPERO注册号：CRD42014009673。
