行动与否：决策过程中的内源性大麻素/多巴胺相互作用
To Act or Not to Act: Endocannabinoid/Dopamine Interactions in Decision-Making.
作者信息
Hernandez Giovanni, Cheer Joseph F
机构信息
Faculté de Pharmacie, Université de Montréal Montréal, Quebec, QC, Canada.
Department of Anatomy and Neurobiology, University of Maryland School of MedicineBaltimore, Maryland, MD, USA; Department of Psychiatry, University of Maryland School of MedicineBaltimore, Maryland, MD, USA.
出版信息
Front Behav Neurosci. 2015 Dec 17;9:336. doi: 10.3389/fnbeh.2015.00336. eCollection 2015.
Abstract
Decision-making is an ethologically adaptive construct that is impaired in multiple psychiatric disorders. Activity within the mesocorticolimbic dopamine system has been traditionally associated with decision-making. The endocannabinoid system through its actions on inhibitory and excitatory synapses modulates dopamine activity and decision-making. The aim of this brief review is to present a synopsis of available data obtained when the endocannabinoid system is manipulated and dopamine activity recorded. To this end, we review research using different behavioral paradigms to provide further insight into how this ubiquitous signaling system biases dopamine-related behaviors to regulate decision-making.
摘要
决策是一种在多种精神疾病中受损的行为适应性结构。中脑边缘多巴胺系统内的活动传统上与决策相关。内源性大麻素系统通过其对抑制性和兴奋性突触的作用来调节多巴胺活动和决策。本简要综述的目的是概述在内源性大麻素系统受到操纵并记录多巴胺活动时获得的现有数据。为此，我们回顾了使用不同行为范式的研究，以进一步深入了解这个普遍存在的信号系统如何使多巴胺相关行为产生偏差以调节决策。
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