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A 19 year follow-up of a woman with lipoprotein lipase deficiency treated with biliopancreatic diversion.对一名接受胆胰转流术治疗的脂蛋白脂肪酶缺乏症女性患者进行的19年随访。
Clin Case Rep. 2015 Nov 5;3(12):1030-3. doi: 10.1002/ccr3.433. eCollection 2015 Dec.
2
Triglyceride-induced diabetes associated with familial lipoprotein lipase deficiency.
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3
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本文引用的文献

1
Chylomicronaemia--current diagnosis and future therapies.乳糜微粒血症——当前的诊断和未来的治疗。
Nat Rev Endocrinol. 2015 Jun;11(6):352-62. doi: 10.1038/nrendo.2015.26. Epub 2015 Mar 3.
2
Genotype-phenotype relationships in patients with type I hyperlipoproteinemia.I型高脂蛋白血症患者的基因型-表型关系
J Clin Lipidol. 2014 May-Jun;8(3):287-95. doi: 10.1016/j.jacl.2014.02.006. Epub 2014 Feb 17.
3
Glycemic variability in relation to oral disposition index in the subjects with different stages of glucose tolerance.血糖变异性与不同糖耐量阶段受试者口服处置指数的关系。
Diabetol Metab Syndr. 2013 Jul 23;5:38. doi: 10.1186/1758-5996-5-38. eCollection 2013.
4
Efficacy and long-term safety of alipogene tiparvovec (AAV1-LPLS447X) gene therapy for lipoprotein lipase deficiency: an open-label trial.载脂蛋白基因疗法治疗脂蛋白脂肪酶缺乏症的疗效和长期安全性：一项开放标签试验
Gene Ther. 2013 Apr;20(4):361-9. doi: 10.1038/gt.2012.43. Epub 2012 Jun 21.
5
HbA(1c)--an analyte of increasing importance.糖化血红蛋白（HbA1c）——一个日益重要的分析物。
Clin Biochem. 2012 Sep;45(13-14):1038-45. doi: 10.1016/j.clinbiochem.2012.06.006. Epub 2012 Jun 14.
6
11-Year follow-up in biliopancreatic diversion for recurrent pancreatitis due to lipoprotein lipase deficiency.因脂蛋白脂肪酶缺乏导致复发性胰腺炎行胆胰转流术的11年随访
J Pediatr Gastroenterol Nutr. 2011 Apr;52(4):499. doi: 10.1097/MPG.0b013e3181f01bb9.
7
Etiology and risk of lactescent plasma and severe hypertriglyceridemia.乳糜血浆和严重高甘油三酯血症的病因和风险。
J Clin Lipidol. 2011 Jan-Feb;5(1):37-44. doi: 10.1016/j.jacl.2010.11.004. Epub 2010 Nov 18.
8
Future challenges for microsomal transport protein inhibitors.微粒体转运蛋白抑制剂的未来挑战。
Curr Vasc Pharmacol. 2009 Jul;7(3):277-86. doi: 10.2174/157016109788340703.
9
Lipoprotein lipase deficiency: benefits and limitations of a novel therapeutic surgical approach.脂蛋白脂肪酶缺乏症：一种新型治疗性手术方法的益处与局限性
J Pediatr Gastroenterol Nutr. 2001 May;32(5):593-5. doi: 10.1097/00005176-200105000-00019.
10
Triglyceride-induced diabetes associated with familial lipoprotein lipase deficiency.
Diabetes. 1999 Jun;48(6):1258-63. doi: 10.2337/diabetes.48.6.1258.

对一名接受胆胰转流术治疗的脂蛋白脂肪酶缺乏症女性患者进行的19年随访。

A 19 year follow-up of a woman with lipoprotein lipase deficiency treated with biliopancreatic diversion.

作者信息

Nosso Gabriella, Capaldo Brunella, Cocozza Sara, Vaccaro Olga

机构信息

Department of Clinical Medicine and Surgery Federico II University of Naples Via S. Pansini 5 Naples 80131 Italy.

出版信息

Clin Case Rep. 2015 Nov 5;3(12):1030-3. doi: 10.1002/ccr3.433. eCollection 2015 Dec.

DOI:10.1002/ccr3.433
PMID:26734140
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4693709/
Abstract

We show the long-term efficacy and safety of modified biliopancreatic diversion for the treatment of LPL-deficiency. How this option compares with gene therapy is difficult to evaluate due to limited experience. Surgery may be the first option in patients in whom medical therapy is ineffective and gene therapy not applicable.

摘要

我们展示了改良胆胰转流术治疗脂蛋白脂肪酶缺乏症的长期疗效和安全性。由于经验有限，很难评估该方法与基因治疗相比的效果。对于药物治疗无效且基因治疗不适用的患者，手术可能是首选方案。