多发性骨髓瘤及相关骨病中的 microRNAs。
MicroRNAs in multiple myeloma and related bone disease.
机构信息
1 Department of Experimental and Clinical Medicine, Magna Graecia University, Campus Salvatore Venuta, Catanzaro, Italy ; 2 Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA.
出版信息
Ann Transl Med. 2015 Dec;3(21):334. doi: 10.3978/j.issn.2305-5839.2015.12.13.
Abstract
MicroRNAs (miRNAs) are short non coding RNAs aberrantly expressed in solid and hematopoietic malignancies where they play a pivotal function as post-transcriptional regulators of gene expression. Recent reports have unveiled a central role of miRNAs in multiple myeloma onset and progression and preclinical findings are progressively disclosing their potential therapeutic value as drugs or targets. In this review, we provide the basic insights of miRNA biology and function, showing how these molecules are extensively dysregulated in malignant plasma cells (PC) and related microenvironment, thus favoring clone survival and proliferation. We here describe how these critical activities have recently been evaluated to design miRNA-based therapies against multiple myeloma cells and its surrounding microenvironment.
摘要
微小 RNA（miRNA）是在实体瘤和血液恶性肿瘤中异常表达的短非编码 RNA，它们作为基因表达的转录后调节因子发挥着关键作用。最近的研究报告揭示了 miRNA 在多发性骨髓瘤发病和进展中的核心作用，临床前研究结果也逐渐揭示了它们作为药物或靶点的潜在治疗价值。在这篇综述中，我们提供了 miRNA 生物学和功能的基本见解，展示了这些分子在恶性浆细胞（PC）及其相关微环境中是如何广泛失调的，从而促进了克隆的存活和增殖。我们在这里描述了如何最近评估这些关键活动，以设计针对多发性骨髓瘤细胞及其周围微环境的基于 miRNA 的治疗方法。
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