Mendaçolli Paola Jung, Brianezi Gabrielli, Schmitt Juliano Vilaverde, Marques Mariângela Esther Alencar, Miot Hélio Amante
Universidade Estadual Paulista, Botucatu, SP, Brazil.
An Bras Dermatol. 2015 Nov-Dec;90(6):874-8. doi: 10.1590/abd1806-4841.20154076.
Histological subtypes of basal cell carcinoma have biological, evolutionary and distinct prognostic behavior. The analysis of characteristics of the nucleus can provide data on their cellular physiology and behavior. The authors of this study evaluated nuclear morphological parameters and textural patterns of chromatin from different subtypes of basal cell carcinoma: nodular (n=37), superficial (n=28) and sclerodermiform (n=28). The parameters were compared between neoplasms' subtypes and with unaffected adjacent basal epithelium. Nuclear area and diameter of sclerodermiform neoplasms were superior to the other subtypes. Chromatin's color intensity and fractal dimension were less intense in superficial subtypes. Nuclear roundness and chromatin's entropy presented lower values in tumors than in normal epithelium. There was significant correlation between morphological and textural variables of normal skin and tumors. Morphometric elements and textural chromatin's homogeneity of basal cell carcinomas may be related to evolutionary, biological and behavior particularities related to each histotype.
基底细胞癌的组织学亚型具有生物学、进化及独特的预后行为。对细胞核特征的分析能够提供有关其细胞生理学和行为的数据。本研究的作者评估了基底细胞癌不同亚型（结节型，n = 37；浅表型，n = 28；硬皮病样型，n = 28）的核形态学参数和染色质纹理模式。这些参数在肿瘤亚型之间以及与未受影响的相邻基底上皮之间进行了比较。硬皮病样型肿瘤的核面积和直径大于其他亚型。浅表亚型中染色质的颜色强度和分形维数较低。肿瘤中核圆度和染色质熵的值低于正常上皮。正常皮肤和肿瘤的形态学与纹理变量之间存在显著相关性。基底细胞癌的形态计量学元素和染色质纹理的均一性可能与每种组织学类型相关的进化、生物学及行为特性有关。
