Kennedy R L, Griffiths H, Gray T A
Department of Medicine, Northern General Hospital, Sheffield, U.K.
Clin Chem. 1989 Sep;35(9):1882-7.
An antiarrhythmic drug, amiodarone, contains 37% iodine by weight and is structurally similar to the thyroid hormones. The drug inhibits hepatic 5'-deiodinase, resulting in increases in serum thyroxin and "reverse" triiodothyronine, whereas the concentration of triiodothyronine in serum is decreased. There is a significant incidence of either hypothyroidism or hyperthyroidism in patients who are being treated with the drug. This is largely the effect of iodine released from the drug during chronic therapy, but in susceptible individuals amiodarone may unmask autoimmune thyroid disease. Some effects of the drug suggest that it may interfere with the action of thyroid hormones at the cellular level, inducing a state of localized hypothyroidism.
抗心律失常药物胺碘酮按重量计含37%的碘，其结构与甲状腺激素相似。该药物抑制肝脏5'-脱碘酶，导致血清甲状腺素和“反式”三碘甲状腺原氨酸增加，而血清中三碘甲状腺原氨酸的浓度降低。接受该药物治疗的患者中，甲状腺功能减退或甲状腺功能亢进的发生率较高。这主要是慢性治疗期间药物释放的碘的作用，但在易感个体中，胺碘酮可能会暴露自身免疫性甲状腺疾病。该药物的一些作用表明，它可能在细胞水平上干扰甲状腺激素的作用，诱发局部甲状腺功能减退状态。
