College of Chemical Engineering and Materials Science, Tianjin University of Science and Technology, Tianjin 300457, China.
Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin 300457, China.
Biosens Bioelectron. 2016 May 15;79:359-63. doi: 10.1016/j.bios.2015.12.071. Epub 2015 Dec 21.
A novel approach to synthesize molecularly imprinted polymer (MIP) nanoparticles using a MIL-101 support (a type of metal-organic framework) is reported herein for the first time; the sample is referred as MIL@MIP. The nanoparticles were well distributed within the polymer film, and exhibit an octahedral shape, satisfied thermal stability, and a high specific surface area (SSA) of 1579.43 m(2)g(-1). The adsorption behavior of MIL@MIP toward metolcarb in aqueous solution was subsequently examined. The synthesized MIL@MIP displayed satisfactory high transfer mass rates and a high selective adsorption affinity for metolcarb. Based on these results, a quartz crystal microbalance (QCM) sensor based on MIL@MIP was subsequently constructed and examined for the sensitive detection of metolcarb. Under optimal conditions, the detection limit of the system assessed in pear juice was 0.0689 mg L(-1) within a linear concentration range of 0.1-0.9 mg L(-1). MIL@MIP-QCM system combines the advantages of MIL-101 and molecularly imprinted technology (MIT), thereby achieving high detection sensitivity and selectivity. The current findings suggest the potential of MIL@MIP for detecting trace level pesticides and veterinary drugs for food safety and environmental control.
本文首次报道了一种使用 MIL-101 作为支撑物（一种金属有机骨架）合成分子印迹聚合物（MIP）纳米粒子的新方法；该样品被称为 MIL@MIP。纳米粒子在聚合物薄膜中分布均匀，呈八面体形状，具有良好的热稳定性和 1579.43 m²/g 的高比表面积（SSA）。随后研究了 MIL@MIP 对水溶液中甲草胺的吸附行为。合成的 MIL@MIP 对甲草胺表现出满意的高传质速率和高选择性吸附亲和力。基于这些结果，随后构建了基于 MIL@MIP 的石英晶体微天平（QCM）传感器，并用于甲草胺的灵敏检测。在最佳条件下，系统在梨汁中的检测限为 0.0689 mg/L，线性浓度范围为 0.1-0.9 mg/L。MIL@MIP-QCM 系统结合了 MIL-101 和分子印迹技术（MIT）的优势，从而实现了高检测灵敏度和选择性。本研究结果表明，MIL@MIP 有望用于检测痕量农药和兽药，以保障食品安全和环境控制。
