Gao Mingkun, Gao Yuhang, Chen Ge, Huang Xiaodong, Xu Xiaomin, Lv Jun, Wang Jing, Xu Donghui, Liu Guangyang
Key Laboratory of Vegetables Quality and Safety Control, Laboratory of Quality & Safety Risk Assessment for Vegetable Products, Ministry of Agriculture and Rural Affairs of China, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, China.
Key Laboratory of Agro-Product Quality and Safety, Key Laboratory of Agro-Product Quality and Safety, Institute of Quality Standard and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Ministry of Agriculture Beijing, Beijing, China.
Front Chem. 2020 Dec 1;8:616326. doi: 10.3389/fchem.2020.616326. eCollection 2020.
Drug residues, organic dyes, heavy metals, and other chemical pollutants not only cause environmental pollution, but also have a serious impact on food safety. Timely and systematic summary of the latest scientific advances is of great importance for the development of new detection technologies. In particular, molecularly imprinted polymers (MIPs) can mimic antibodies, enzymes and other biological molecules to recognize, enrich, and separate contaminants, with specific recognition, selective adsorption, high affinity, and strong resistance characteristics. Therefore, MIPs have been widely used in chemical analysis, sensing, and material adsorption. In this review, we first describe the basic principles and production processes of molecularly imprinted polymers. Secondly, an overview of recent applications of molecularly imprinted polymers in sample pre-treatment, sensors, chromatographic separation, and mimetic enzymes is highlighted. Finally, a brief assessment of current technical issues and future trends in molecularly imprinted polymers is also presented.
药物残留、有机染料、重金属及其他化学污染物不仅会造成环境污染,还会对食品安全产生严重影响。及时且系统地总结最新科学进展对于新型检测技术的发展至关重要。特别是,分子印迹聚合物(MIPs)能够模拟抗体、酶及其他生物分子来识别、富集和分离污染物,具有特异性识别、选择性吸附、高亲和力和强抗性等特点。因此,MIPs已广泛应用于化学分析、传感及材料吸附领域。在本综述中,我们首先描述了分子印迹聚合物的基本原理和制备过程。其次,重点概述了分子印迹聚合物在样品预处理、传感器、色谱分离及模拟酶方面的近期应用。最后,还对分子印迹聚合物当前的技术问题和未来趋势进行了简要评估。