锑剂用于治疗对脂质体两性霉素B无反应的内脏利什曼病。
Antimony to Cure Visceral Leishmaniasis Unresponsive to Liposomal Amphotericin B.
作者信息
Morizot Gloria, Jouffroy Romain, Faye Albert, Chabert Paul, Belhouari Katia, Calin Ruxandra, Charlier Caroline, Miailhes Patrick, Siriez Jean-Yves, Mouri Oussama, Yera Hélène, Gilquin Jacques, Tubiana Roland, Lanternier Fanny, Mamzer Marie-France, Legendre Christophe, Peyramond Dominique, Caumes Eric, Lortholary Olivier, Buffet Pierre
机构信息
Plateforme ICAReB, Institut Pasteur, Paris, France.
Service d'anesthésie-réanimation, Hôpital Necker, Paris, France.
出版信息
PLoS Negl Trop Dis. 2016 Jan 6;10(1):e0004304. doi: 10.1371/journal.pntd.0004304. eCollection 2016 Jan.
We report on 4 patients (1 immunocompetent, 3 immunosuppressed) in whom visceral leishmaniasis had become unresponsive to (or had relapsed after) treatment with appropriate doses of liposomal amphotericin B. Under close follow-up, full courses of pentavalent antimony were administered without life-threatening adverse events and resulted in rapid and sustained clinical and parasitological cure.
我们报告了4例患者（1例免疫功能正常，3例免疫抑制），这些患者的内脏利什曼病在用适当剂量的脂质体两性霉素B治疗后无反应（或治疗后复发）。在密切随访下，给予了全疗程的五价锑，未发生危及生命的不良事件，并实现了快速且持续的临床和寄生虫学治愈。
Zotero 插件