Whitfield J B
Department of Clinical Biochemistry, Royal Pr ince Alfred Hospital, Camperdown NSW, Australia.
Addict Biol. 1997 Oct;2(4):377-86. doi: 10.1080/13556219772435.
Where the experience of alcohol is unpleasant because of adverse reactions to small amounts, alcohol consumption is likely to be low and alcohol dependence rare. This is shown by many studies of Asian subjects who experience the alcohol flush reaction (AFR) due to inherited aldehyde dehydrogenase (ALDH) deficiency. Alcohol reactions are less common and on average less severe in non-Asian subjects, but they do occur and can affect alcohol consumption. Information about alcohol reactions and their consequences in Europeans is reviewed, and such reactions are compared with those caused by mitochondrial ALDH deficiency in Asians.
如果由于对少量酒精产生不良反应而导致饮酒体验不愉快，那么酒精消费量可能较低，酒精依赖也很少见。许多针对亚洲受试者的研究表明了这一点，这些受试者由于遗传性乙醛脱氢酶（ALDH）缺乏而出现酒精潮红反应（AFR）。在非亚洲受试者中，酒精反应不太常见，平均也不那么严重，但确实会发生，并且会影响酒精消费。本文综述了欧洲人酒精反应及其后果的相关信息，并将此类反应与亚洲人线粒体ALDH缺乏引起的反应进行了比较。
