Koffler M, Ramirez L C, Raskin P
University of Texas Southwestern Medical Center, Department of Internal Medicine, Dallas 75235.
Diabetes Res Clin Pract. 1989 Aug 1;7(2):83-98. doi: 10.1016/0168-8227(89)90098-3.
The issue of the peripheral resistance to insulin action has been getting a lot of attention over the last decade. The reason for this is that insulin is a major regulatory hormone and is involved in the metabolism of carbohydrates, lipids, protein and ions. To understand the pathophysiology of insulin resistance it is necessary to elucidate the methods for the assessment of insulin resistance and the molecular mechanism of insulin action. Insulin action is impaired in pathologic and physiologic states such as diabetes mellitus and obesity as well as in some rare syndromes. Further understanding of the pathophysiology of the impaired action of insulin improves the chances of defining new ways of treatment to improve the sensitivity to insulin action.
在过去十年中，胰岛素作用的外周抵抗问题备受关注。原因在于胰岛素是一种主要的调节激素，参与碳水化合物、脂质、蛋白质和离子的代谢。为了解胰岛素抵抗的病理生理学，有必要阐明胰岛素抵抗的评估方法以及胰岛素作用的分子机制。在糖尿病、肥胖等病理和生理状态以及一些罕见综合征中，胰岛素作用会受损。进一步了解胰岛素作用受损的病理生理学，有助于增加确定改善胰岛素作用敏感性新治疗方法的机会。
