Carpentier J L
Institute of Histology and Embryology, University of Geneva, Switzerland.
Diabetologia. 1989 Sep;32(9):627-35. doi: 10.1007/BF00274248.
Following initial binding to specific cell surface receptors insulin is internalized in target cells. The fate of the internalized insulin-receptor complexes and how the processes involved are regulated is reviewed. The implications of these events in the effects of insulin on its target cells and in the physiopathology of diabetes and insulin resistance states are also considered.
胰岛素最初与特定细胞表面受体结合后，会被内化到靶细胞中。本文综述了内化的胰岛素-受体复合物的命运以及相关过程的调控方式。还探讨了这些事件对胰岛素作用于靶细胞的影响以及在糖尿病和胰岛素抵抗状态病理生理学中的意义。
