Ticcinelli Valentina, Stankovski Tomislav, McClintock Peter V E, Stefanovska Aneta
Annu Int Conf IEEE Eng Med Biol Soc. 2015;2015:7366-9. doi: 10.1109/EMBC.2015.7320093.
The balance and functionality of the cardiovascular system are maintained by a network of couplings between the different oscillations involved. We study the effect of ageing on these interactions through the application of wavelet analysis, and by the use of dynamical Bayesian inference to compute coupling functions. The method, applied to phases extracted from microvascular flow recorded by laser Doppler flowmetry (LDF), reveals the coupling functions between oscillations propagated to the smallest vessels. Consistent with earlier work based on analysis of cardiac and respiratory phases obtained from direct measurements, our analysis demonstrates an impairment of the propagated cardio-respiratory coupling with ageing. The coupling weakens despite the increased cardiac component in the LDF with ageing. Our results bring new insight to the effect of ageing on cardiovascular regulation that might help improve the diagnostic potential of LDF monitors.
心血管系统的平衡和功能由所涉及的不同振荡之间的耦合网络维持。我们通过应用小波分析以及使用动态贝叶斯推理来计算耦合函数，研究衰老对这些相互作用的影响。该方法应用于从激光多普勒血流仪（LDF）记录的微血管血流中提取的相位，揭示了传播到最小血管的振荡之间的耦合函数。与早期基于直接测量获得的心脏和呼吸相位分析的工作一致，我们的分析表明，随着年龄增长，传播的心肺耦合会受损。尽管随着年龄增长LDF中的心脏成分增加，但耦合仍会减弱。我们的结果为衰老对心血管调节的影响带来了新的见解，这可能有助于提高LDF监测器的诊断潜力。
