糖尿病易感性BB/OK大鼠血清对新生大鼠胰岛及胰岛细胞悬液的影响。
Effect of serum from diabetes-prone BB/OK rats on neonatal rat pancreatic islets and islet cell suspensions.
作者信息
Schröder D, Hehmke B, Klöting I, Besch W
机构信息
Central Institute of Diabetes, Karlsburg, GDR.
出版信息
Exp Clin Endocrinol. 1989 May;93(2-3):187-92. doi: 10.1055/s-0029-1210855.
PMID:2673813
Abstract
Humoral-mediated cytolytic activity against neonatal rat pancreatic islet cells as well as islets of Langerhans was detected in sera of newly diagnosed diabetic BB/OK rats by measurement of enhanced 51Cr-release or insulin leakage. Beta-cell-specific functions of islet cell suspensions such as insulin secretion and (pro)insulin biosynthesis can be affected by BB rat serum in vitro.
摘要
通过测量增强的51Cr释放或胰岛素泄漏，在新诊断的糖尿病BB/OK大鼠的血清中检测到针对新生大鼠胰岛细胞以及胰岛的体液介导的细胞溶解活性。胰岛细胞悬液的β细胞特异性功能，如胰岛素分泌和（原）胰岛素生物合成，在体外可受到BB大鼠血清的影响。
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