Jablenska R
Department of Anatomy and Histology, Medical Academy, Sofia, Bulgaria.
Exp Clin Endocrinol. 1989 May;93(2-3):208-12. doi: 10.1055/s-0029-1210858.
Treatment with the immunosuppressive agent Cyclosporin A frequently gives rise to alteration of function in the Langerhans islet which may result in diabetes. Light microscopy, immunocytochemical, and electron microscopic investigations demonstrate degranulation and vacuolization of B endocrine pancreatic cells in treated animals. Similar changes, but to a milder degree, are observed in the A-cells. The morphological alterations described are likely to result from an inhibition of the synthesis and secretion of B-cells.
使用免疫抑制剂环孢菌素A进行治疗常常会引起朗格汉斯胰岛功能改变，这可能导致糖尿病。光学显微镜、免疫细胞化学和电子显微镜研究表明，接受治疗的动物的胰腺B内分泌细胞出现脱颗粒和空泡化现象。在A细胞中也观察到了类似变化，但程度较轻。所描述的形态学改变可能是由于B细胞的合成和分泌受到抑制所致。
