Frost J A, Smith H R, Willshaw G A, Scotland S M, Gross R J, Rowe B
Division of Enteric Pathogens, Central Public Health Laboratory, London.
Epidemiol Infect. 1989 Aug;103(1):73-81. doi: 10.1017/s0950268800030375.
Vero-cytotoxin (VT) producing Escherichia coli serogroup O157 have been isolated from patients with diarrhoea, haemorrhagic colitis (HC) and haemolytic uraemic syndrome (HUS). A phage-typing scheme developed in Canada has been used to type 155 VT+ E. coli O157 serogroup isolated from sporadic infections in the UK since 1983, and 48 strains from HC or HUS outbreaks. Twelve phage types were identified of which three, types 49, 51 and 52, have not been found in North America. All strains carried a 60 x 10(6) plasmid and most VT1+VT2+ strains also had a 5 x 10(6) plasmid coding for colicin D production. The majority of strains producing both VT1 and VT2 belonged to phage type 1, or the related types 4, 8 and 14. Most strains producing only VT2 belonged to types 2 or 49. Four outbreaks were included in the survey. Three had strains of a single phage type while strains from the fourth outbreak were more variable. The distribution of phage types throughout the UK showed no marked geographical variations.
从腹泻、出血性结肠炎（HC）和溶血尿毒综合征（HUS）患者中分离出了产志贺毒素（VT）的大肠杆菌O157血清型。加拿大制定的一种噬菌体分型方案已用于对自1983年以来从英国散发性感染中分离出的155株产VT大肠杆菌O157血清型以及48株来自HC或HUS暴发的菌株进行分型。鉴定出了12种噬菌体类型，其中3种，即49型、51型和52型，在北美尚未发现。所有菌株都携带一个60×10⁶的质粒，大多数产VT1+VT2+的菌株还具有一个编码产大肠杆菌素D的5×10⁶质粒。大多数同时产生VT1和VT2的菌株属于噬菌体1型或相关的4型、8型和14型。大多数仅产生VT2的菌株属于2型或49型。调查包括4次暴发。其中3次暴发的菌株为单一噬菌体类型，而第四次暴发的菌株则更具多样性。噬菌体类型在英国各地的分布没有明显的地理差异。
