Green Jonathan, Leadbitter Kathy, Kay Catherine, Sharma Kishan
Social Development Research Group, Institute of Brain Behaviour and Mental Health, University of Manchester, Room 3.311, Jean McFarlane Building, Oxford Road, Manchester, M13 9PL, UK.
Pennine Care NHS Foundation Trust, 225 Old St, Ashton-under-Lyne, Manchester, Lancashire, OL6 7SR, UK.
J Autism Dev Disord. 2016 Apr;46(4):1392-402. doi: 10.1007/s10803-015-2680-6.
Syndromic autism has been described in children adopted after orphanage rearing. We investigated whether the same existed in children adopted after family breakdown. Families of 54/60 adopted children aged 6-11 years (mean 102 months; SD 20; 45% male) returned screening questionnaires for autism spectrum disorder (ASD); 21/54 (39%) screened positive. Detailed in-person phenotyping of screen positive cases showed ASD in 6/54 (11%), Broad ASD (sub threshold traits) in 10/54 (18.5%); 5/54 (9%) screened false positive. The ASD group showed impairments across both social communication and restrictive repetitive behaviour domains, Broad ASD was more mixed. These rates, much higher than population prevalence, are comparable with institutionalised samples. There are implications for developmental science, and assessment, treatment and policy for adopted children.
孤儿院抚养后被收养儿童中曾有综合征性自闭症的描述。我们调查了家庭破裂后被收养儿童中是否也存在同样情况。60名6至11岁(平均102个月;标准差20;45%为男性)被收养儿童的家庭返回了自闭症谱系障碍(ASD)筛查问卷;54份问卷中有21份(39%)筛查呈阳性。对筛查呈阳性病例进行的详细面对面表型分析显示,54份中有6份(11%)为ASD,54份中有10份(18.5%)为广泛ASD(亚阈值特征);54份中有5份(9%)筛查为假阳性。ASD组在社交沟通和限制性重复行为领域均有损害,广泛ASD则更为复杂。这些比率远高于总体患病率,与机构收养样本相当。这对发育科学以及被收养儿童的评估、治疗和政策都有影响。