Witz G
UMDNJ--Robert Wood Johnson Medical School, Department of Environmental and Community Medicine, Piscataway 08854.
Free Radic Biol Med. 1989;7(3):333-49. doi: 10.1016/0891-5849(89)90137-8.
This article describes the chemical nature of alpha,beta-unsaturated aldehydes and some of their toxicological effects based on their ability to function as direct-acting alkylating agents. Selected compounds discussed include alpha,beta-unsaturated aldehydic environmental pollutants, metabolites of xenobiotics and natural products, and lipid peroxidation--and DNA oxidation products derived from cellular constituents. Briefly reviewed are sources and mechanisms of formation of the aldehydes, their reactivity with respect to glutathione and amino-groups, their toxicity based on interaction with sulfhydryl and amino targets in cells, and modulation of their toxicity by metabolism.
本文描述了α,β-不饱和醛的化学性质，以及基于其作为直接作用烷基化剂的功能所产生的一些毒理学效应。所讨论的选定化合物包括α,β-不饱和醛类环境污染物、异生物素和天然产物的代谢物，以及细胞成分衍生的脂质过氧化和DNA氧化产物。简要回顾了醛的来源和形成机制、它们与谷胱甘肽和氨基的反应性、基于与细胞中巯基和氨基靶点相互作用的毒性，以及代谢对其毒性的调节。
