Kim Hyun Chull, Sohng Seung Hyun, Shin Dong Hoon, Choi Jong Soo, Bae Young Kyung
Department of Dermatology, Yeungnam University College of Medicine, Daegu, Korea.
Department of Pathology, Yeungnam University College of Medicine, Daegu, Korea.
Int J Dermatol. 2016 Jan;55(1):36-44. doi: 10.1111/ijd.12771.
Basal cell carcinoma (BCC) is the most common cutaneous neoplasm. Despite numerous previous studies, the origin of BCC is still controversial.
The aim of this study is to evaluate whether BCC arises from the hair follicle rather than the epidermal basal cell.
The labeling index and differences of expression of the immunohistochemical (IHC) stainings of CK15, CK19, follistatin, and Bmi-1 were evaluated in 20 cases of BCC, 13 cases of trichoblastoma, 21 cases of actinic keratosis (AK), and 19 cases of squamous cell carcinoma (SCC) which were biopsied in the department of dermatology of the Yeungnam University Medical Center.
For CK15, labeling indexes of BCC (83.0%) and trichoblastoma (84.4%) were significantly higher than those of AK (15.9%) and SCC (15.8%). For CK19, labeling indexes of BCC (8.1%), trichoblastoma (6.6%), AK (3.5%), and SCC (14.8%) revealed no difference. For follistatin, labeling indexes of BCC (51.1%) and trichoblastoma (70.1%) were significantly higher than those of AK (0.9%) and SCC (8.5%). For Bmi-1, labeling indexes of BCC (74.4%) and trichoblastoma (84.7%) were significantly higher than those of AK (24.7%) and SCC (18.6%).
In this study, strong positivity of CK15, follistatin, and Bmi-1 was more frequently observed in BCC and trichoblastoma than in SCC and AK. These findings suggest that BCC and trichoblastoma share the same differentiation toward the hair follicle. Furthermore, CK15, follistatin, and Bmi-1 can be useful as markers to differentiate BCC from SCC.
基底细胞癌（BCC）是最常见的皮肤肿瘤。尽管此前有众多研究，但BCC的起源仍存在争议。
本研究旨在评估BCC是否起源于毛囊而非表皮基底细胞。
在庆南大学医学中心皮肤科活检的20例BCC、13例毛母细胞瘤、21例光化性角化病（AK）和19例鳞状细胞癌（SCC）中，评估CK15、CK19、卵泡抑素和Bmi-1免疫组化（IHC）染色的标记指数及表达差异。
对于CK15，BCC（83.0%）和毛母细胞瘤（84.4%）的标记指数显著高于AK（15.9%）和SCC（15.8%）。对于CK19，BCC（8.1%）、毛母细胞瘤（6.6%）、AK（3.5%）和SCC（14.8%）之间的标记指数无差异。对于卵泡抑素，BCC（51.1%）和毛母细胞瘤（70.1%）的标记指数显著高于AK（0.9%）和SCC（8.5%）。对于Bmi-1，BCC（74.4%）和毛母细胞瘤（84.7%）的标记指数显著高于AK（24.7%）和SCC（18.6%）。
在本研究中，BCC和毛母细胞瘤中CK15、卵泡抑素和Bmi-1的强阳性表达比SCC和AK更常见。这些发现表明BCC和毛母细胞瘤对毛囊具有相同的分化方向。此外，CK15、卵泡抑素和Bmi-1可作为区分BCC和SCC的有用标记物。
