Chung Hye Soo, Lee Min Jung, Hwang Soon Young, Lee Hyun Jung, Yoo Hye Jin, Seo Ji-A, Kim Sin Gon, Kim Nan Hee, Baik Sei Hyun, Choi Dong Seop, Kim Seon Mi, Choi Kyung Mook
Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea.
Department of Biostatistics, College of Medicine, Korea University, Seoul, Korea.
Cardiovasc Diabetol. 2016 Jan 6;15:1. doi: 10.1186/s12933-015-0324-y.
Previous studies have shown that angiopoietin-like protein 8 (ANGPTL8), also called as betatrophin, acts together with ANGPTL3 to regulate lipid metabolism, glucose metabolism, and energy homeostasis. Moreover, ANGPTL8 promotes proliferation of pancreatic β-cells and induces insulin secretion. However, there are no previous longitudinal studies in humans.
We analyzed the age- and sex-matched data of 240 normal weight and overweight Korean children from the Korean Metabolic disorders and Obesity Study in Elementary School children (K-MOSES), a prospective observational cohort study.
At baseline, ANGPTL8 concentrations were positively associated with triglycerides (TG) (r = 0.168, P = 0.010), whereas ANGPTL3 levels were associated with fasting insulin (r = 0.248, P < 0.001) and the homeostasis model assessment of insulin resistance (HOMA-IR) (r = 0.197, P = 0.002). Although both ANGPTL8 and ANGPTL3 levels did not differ between children with normal weight and children with overweight, ANGPTL8 levels were increased in males compared to females (341.2 [267.4-436.5] vs. 270.2 [213.9-378.8] pg/ml, P = 0.001). In particular, there was no significant inter-relationship between circulating ANGPTL8 and ANGPTL3 concentrations in Korean boys and girls (r = -0.073, P = 0.265). Multivariate analysis showed that baseline ANGPTL8 concentrations were independently associated with future changes of serum TG levels in Korean children after adjusting for confounding factors after a 3 year follow-up period (r = -0.165, P = 0.016).
This longitudinal study demonstrated for the first time that baseline ANGPTL8 levels were associated with baseline and future changes in TG levels in Korean children.
既往研究表明，血管生成素样蛋白8（ANGPTL8），也称为β-促胰岛素分泌素，与ANGPTL3共同作用调节脂质代谢、葡萄糖代谢和能量稳态。此外，ANGPTL8可促进胰腺β细胞增殖并诱导胰岛素分泌。然而，此前尚无针对人类的纵向研究。
我们分析了来自韩国小学生代谢紊乱与肥胖研究（K-MOSES）的240名体重正常和超重的韩国儿童的年龄和性别匹配数据，这是一项前瞻性观察队列研究。
在基线时，ANGPTL8浓度与甘油三酯（TG）呈正相关（r = 0.168，P = 0.010），而ANGPTL3水平与空腹胰岛素（r = 0.248，P < 0.001）和胰岛素抵抗稳态模型评估（HOMA-IR）（r = 0.197，P = 0.002）相关。虽然体重正常儿童和超重儿童的ANGPTL8和ANGPTL3水平均无差异，但男性的ANGPTL8水平高于女性（341.2 [267.4 - 436.5] vs. 270.2 [213.9 - 378.8] pg/ml，P = 0.001）。特别是，韩国男孩和女孩循环中的ANGPTL8和ANGPTL3浓度之间没有显著的相互关系（r = -0.073，P = 0.265）。多变量分析显示，在调整混杂因素后，基线ANGPTL8浓度与3年随访期后韩国儿童血清TG水平的未来变化独立相关（r = -0.165，P = 0.016）。
这项纵向研究首次证明，基线ANGPTL8水平与韩国儿童的基线TG水平及未来变化相关。
