铁催化α-氨基羰基化合物与吲哚的直接α-芳基化反应。
Iron-catalyzed direct α-arylation of α-amino carbonyl compounds with indoles.
作者信息
Zhang Yan, Ni Minjie, Feng Bainian
机构信息
School of Pharmaceutical Science, Jiangnan University, Wuxi 214122, P. R. China.
出版信息
Org Biomol Chem. 2016 Feb 7;14(5):1550-4. doi: 10.1039/c5ob02325d.
PMID:26739751
Abstract
A mild and general α-arylation of α-amino carbonyls with indoles catalyzed by Fe(ClO4)3 has been developed. C-H activation is smoothly fulfilled by using TBHP as the oxidant with good yields. Two hydrogen dissociations make this transformation more environmentally benign because of high atom efficiency.
摘要
已开发出一种由高氯酸铁催化的温和且通用的α-氨基羰基与吲哚的α-芳基化反应。以叔丁基过氧化氢（TBHP）作为氧化剂能顺利实现C-H活化，产率良好。由于原子效率高，两次氢解离使该转化过程对环境更为友好。
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