活动性多发性骨髓瘤患者肥大细胞密度与血管生成细胞因子的相关性
Correlation of Mast Cell Density With Angiogenic Cytokines in Patients With Active Multiple Myeloma.
作者信息
Vyzoukaki Rodanthi, Tsirakis George, Pappa Constantina A, Androulakis Nikolaos, Kokonozaki Maria, Tzardi Maria, Alexandrakis Michael G
机构信息
Hematology Laboratory, University Hospital of Heraklion, Heraklion, Greece.
Hematology Department, General Hospital of Chania, Chania, Greece.
出版信息
Clin Ther. 2016 Feb;38(2):297-301. doi: 10.1016/j.clinthera.2015.11.022. Epub 2015 Dec 28.
PURPOSE
The aim of the study is to estimate whether bone marrow mast cell density (MCD) in multiple myeloma (MM) correlates with circulating levels of various angiogenic factors.
METHODS
In 70 patients with newly diagnosed active MM, we measured MCD using immunohistochemical stain for tryptase and serum levels of matrix metalloproteinase 9 (MMP-9), angiopoietin 2 (ANGIOP-2), and angiogenin (ANG) with ELISA.
FINDINGS
Levels of MCD, ANGIOP-2, and ANG were significantly higher in MM patients compared with the control group. The MMP-9 level was higher in MM patients compared with the control group but without statistical significance. All values were increasing in parallel with clinical stages. Furthermore, MCD correlated positively with MMP-9, ANGIOP-2, and ANG.
IMPLICATIONS
MCs participate in the angiogenic processes of MM, with complex implicated mechanisms. This interplay between MCs and the other participants favors angiogenesis and MM growth.
目的
本研究旨在评估多发性骨髓瘤（MM）患者的骨髓肥大细胞密度（MCD）是否与多种血管生成因子的循环水平相关。
方法
在70例新诊断的活动性MM患者中，我们采用免疫组化法检测色氨酸酶以测量MCD，并采用酶联免疫吸附测定法（ELISA）检测血清基质金属蛋白酶9（MMP-9）、血管生成素2（ANGIOP-2）和血管生成素（ANG）的水平。
结果
与对照组相比，MM患者的MCD、ANGIOP-2和ANG水平显著更高。MM患者的MMP-9水平高于对照组，但无统计学意义。所有数值均随临床分期平行升高。此外，MCD与MMP-9、ANGIOP-2和ANG呈正相关。
结论
肥大细胞参与MM的血管生成过程，其机制复杂。肥大细胞与其他参与者之间的这种相互作用有利于血管生成和MM生长。
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