Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, 70124 Bari, Italy.
Department of Biomedical Sciences, and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, 70124 Bari, Italy.
Int J Mol Sci. 2019 Jan 23;20(3):481. doi: 10.3390/ijms20030481.
Bone marrow angiogenesis plays an important role in the pathogenesis and progression of hematological malignancies. It is well known that tumor microenvironment promotes tumor angiogenesis, proliferation, invasion, and metastasis, and also mediates mechanisms of therapeutic resistance. An increased number of mast cells has been demonstrated in angiogenesis associated with hematological tumors. In this review we focused on the role of mast cells in angiogenesis in human plasma cell malignancies. In this context, mast cells might act as a new target for the adjuvant treatment of these tumors through the selective inhibition of angiogenesis, tissue remodeling and tumor-promoting molecules, permitting the secretion of cytotoxic cytokines and preventing mast cell-mediated immune suppression.
骨髓血管生成在血液系统恶性肿瘤的发病机制和进展中起着重要作用。众所周知，肿瘤微环境促进肿瘤血管生成、增殖、侵袭和转移，并介导治疗耐药机制。在与血液系统肿瘤相关的血管生成中，已经证明有更多的肥大细胞存在。在这篇综述中，我们重点关注肥大细胞在人类浆细胞恶性肿瘤血管生成中的作用。在这种情况下，通过选择性抑制血管生成、组织重塑和促进肿瘤的分子，肥大细胞可能成为这些肿瘤辅助治疗的一个新靶点，从而允许细胞毒性细胞因子的分泌，并防止肥大细胞介导的免疫抑制。
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