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2010年至2014年期间,芬兰通过自动化多分析物mariPOC®呼吸道病原体检测获得的呼吸道感染综合实时流行病学数据。

Comprehensive real-time epidemiological data from respiratory infections in Finland between 2010 and 2014 obtained from an automated and multianalyte mariPOC® respiratory pathogen test.

作者信息

Gunell M, Antikainen P, Porjo N, Irjala K, Vakkila J, Hotakainen K, Kaukoranta S S, Hirvonen J J, Saha K, Manninen R, Forsblom B, Rantakokko-Jalava K, Peltola V, Koskinen J O, Huovinen P

机构信息

Medical Microbiology and Immunology Unit, University of Turku, Kiinamyllynkatu 13, 20520, Turku, Finland.

TYKS-Sapa, Microbiology and Genetics Service Area, Microbiology Branch, Turku University Hospital, Turku, Finland.

出版信息

Eur J Clin Microbiol Infect Dis. 2016 Mar;35(3):405-13. doi: 10.1007/s10096-015-2553-0. Epub 2016 Jan 6.

DOI:10.1007/s10096-015-2553-0
PMID:26740322
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7088327/
Abstract

Respiratory viruses cause seasonal epidemics every year. Several respiratory pathogens are circulating simultaneously and typical symptoms of different respiratory infections are alike, meaning it is challenging to identify and diagnose different respiratory pathogens based on symptoms alone. mariPOC® is an automated, multianalyte antigen test which allows the rapid detection of nine respiratory infection pathogens [influenza A and B viruses, respiratory syncytial virus (RSV), human metapneumovirus, adenovirus, parainfluenza 1-3 viruses and pneumococci] from a single nasopharyngeal swab or aspirate samples, and, in addition, can be linked to laboratory information systems. During the study period from November 2010 to June 2014, a total of 22,485 multianalyte respi tests were performed in the 14 participating laboratories in Finland and, in total, 6897 positive analyte results were recorded. Of the tested samples, 25 % were positive for one respiratory pathogen, with RSV (9.8 %) and influenza A virus (7.2 %) being the most common findings, and 0.65 % of the samples were multivirus-positive. Only small geographical variations in seasonal epidemics occurred. Our results show that the mariPOC® multianalyte respi test allows simultaneous detection of several respiratory pathogens in real time. The results are reliable and give the clinician a picture of the current epidemiological situation, thus minimising guesswork.

摘要

呼吸道病毒每年都会引发季节性流行。多种呼吸道病原体同时传播,且不同呼吸道感染的典型症状相似,这意味着仅根据症状来识别和诊断不同的呼吸道病原体具有挑战性。mariPOC®是一种自动化的多分析物抗原检测方法,可从单个鼻咽拭子或吸出物样本中快速检测出九种呼吸道感染病原体[甲型和乙型流感病毒、呼吸道合胞病毒(RSV)、人偏肺病毒、腺病毒、副流感1 - 3型病毒和肺炎球菌],此外,还可与实验室信息系统相连。在2010年11月至2014年6月的研究期间,芬兰14个参与研究的实验室共进行了22485次多分析物呼吸检测,总共记录到6897次阳性分析物结果。在检测的样本中,25%的样本对一种呼吸道病原体呈阳性,其中RSV(9.8%)和甲型流感病毒(7.2%)最为常见,0.65%的样本为多病毒阳性。季节性流行仅出现了很小的地理差异。我们的结果表明,mariPOC®多分析物呼吸检测能够实时同时检测多种呼吸道病原体。结果可靠,能让临床医生了解当前的流行病学情况,从而最大限度地减少猜测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/705e/7088327/d2e20c11eab1/10096_2015_2553_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/705e/7088327/04db287de18b/10096_2015_2553_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/705e/7088327/6d3d20776b01/10096_2015_2553_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/705e/7088327/0eb8e3b697a5/10096_2015_2553_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/705e/7088327/02098e49b80c/10096_2015_2553_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/705e/7088327/d2e20c11eab1/10096_2015_2553_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/705e/7088327/04db287de18b/10096_2015_2553_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/705e/7088327/6d3d20776b01/10096_2015_2553_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/705e/7088327/0eb8e3b697a5/10096_2015_2553_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/705e/7088327/02098e49b80c/10096_2015_2553_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/705e/7088327/d2e20c11eab1/10096_2015_2553_Fig5_HTML.jpg

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