Demir Fikri, Karadeniz Cem, Özdemir Rahmi, Yozgat Yılmaz, Çelegen Kübra, Karaaslan Utku, Demirol Mustafa, Meşe Timur, Ünal Nurettin
Department of Pediatric Cardiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
Department of Pediatric Cardiology, Behçet Uz Children's Hospital, İzmir, Turkey.
Balkan Med J. 2015 Oct;32(4):371-6. doi: 10.5152/balkanmedj.2015.151108. Epub 2015 Oct 1.
Kawasaki disease is an inflammatory condition. Neutrophil to lymphocyte ratio is a marker reflecting inflammation.
The aim of the study is to evaluate usefulness of neutrophil to lymphocyte ratio in diagnosis of Kawasaki disease and in prediction of coronary artery lesions.
Retrospective cross-sectional study.
Seventy-five children with Kawasaki disease and 66 controls were retrospectively enrolled. Their leukocyte, neutrophil, and lymphocyte counts were recorded. Abnormally distributed data were shown as median (interquartile range). Cases having coronary artery diameter two standard deviation above mean were diagnosed to have coronary artery lesions.
Median age of Kawasaki disease patients was 34 months. Twentyfive of those (33.33%) had incomplete Kawasaki disease and twenty-six (34.66%) had coronary artery lesions. Leukocyte [12.61 (6.09)×10(3)/µL vs. 8.48 (5.58)×10(3)/µL], neutrophil [6.73 (4.10) ×10(3)/µL vs. 4.62 (5.47)×10(3)/µL], and lymphocyte [4.04 (2.91)×10(3)/µL vs. 3.02 (2.57) ×10(3)/µL] counts were significantly higher in Kawasaki disease patients compared to controls (all p values <0.01). However, there was not significant difference between patients and controls regarding neutrophil to lymphocyte ratio [1.72 (1.22) vs. 1.71 (1.88)]. Findings of Kawasaki disease and incomplete Kawasaki disease cases did not differ, while comparison of patients with and without coronary artery lesions revealed significantly higher neutrophil to lymphocyte ratio values in former group [2.02 (1.63) vs. 1.50 (1.28), p=0.01]. The cut-off neutrophil to lymphocyte ratio value for prediction of coronary artery lesions was determined as 1.32.
Neutrophil to lymphocyte ratio values in Kawasaki patients with coronary lesions were significantly higher than the ones without and values greater than 1.32 were useful in prediction of coronary lesions.
川崎病是一种炎症性疾病。中性粒细胞与淋巴细胞比值是反映炎症的一个指标。
本研究旨在评估中性粒细胞与淋巴细胞比值在川崎病诊断及冠状动脉病变预测中的作用。
回顾性横断面研究。
回顾性纳入75例川崎病患儿及66例对照。记录他们的白细胞、中性粒细胞及淋巴细胞计数。异常分布的数据以中位数（四分位间距）表示。冠状动脉直径超过均值两个标准差的病例被诊断为有冠状动脉病变。
川崎病患者的中位年龄为34个月。其中有25例（33.33%）为不完全川崎病，26例（34.66%）有冠状动脉病变。与对照组相比，川崎病患者的白细胞[12.61（6.09）×10³/µL对8.48（5.58）×10³/µL]、中性粒细胞[6.73（4.10）×10³/µL对4.62（5.47）×10³/µL]及淋巴细胞[4.04（2.91）×10³/µL对3.02（2.57）×10³/µL]计数显著更高（所有p值<0.01）。然而，患者与对照组在中性粒细胞与淋巴细胞比值方面无显著差异[1.72（1.22）对1.71（1.88）]。川崎病病例与不完全川崎病病例的结果无差异，而有冠状动脉病变与无冠状动脉病变患者的比较显示，前一组的中性粒细胞与淋巴细胞比值显著更高[2.02（1.63）对1.50（1.2），p = 0.01]。预测冠状动脉病变的中性粒细胞与淋巴细胞比值临界值确定为1.32。
有冠状动脉病变的川崎病患者的中性粒细胞与淋巴细胞比值显著高于无病变者，大于1.32的值有助于预测冠状动脉病变。
