Gil HyunJi, Bae Kyoung-Hee, Kim LiJung, Kim SungChul, Soh Kwang-Sup
Nano Primo Research Center, Advanced Institute of Convergence Technology, Seoul National University, Suwon, South Korea.
Nano Primo Research Center, Advanced Institute of Convergence Technology, Seoul National University, Suwon, South Korea; College of Bionano Technology, Gachon University, Seongnam, South Korea.
J Acupunct Meridian Stud. 2015 Dec;8(6):288-93. doi: 10.1016/j.jams.2015.03.007. Epub 2015 Apr 8.
Mast cells (MCs) play a major role in allergic reactions. Surprisingly, the acupuncture points have a higher density of MCs compared with nonacupoints in the skin, which is consistent with the augmentation of the immune function by acupuncture treatment. We hypothesized that the primo vascular system (PVS), which was proposed as the anatomical structure of the acupuncture points and meridians, should have a high density of MCs. In order to test that hypothesis, we investigated the primo nodes isolated from the surfaces of internal organs, such as the liver, the small and the large intestines, and the bladder. The harvested primo nodes were stained with toluidine blue, and the MCs were easily recognized by their red-purple stains and their characteristic granules. The results showed a high density of MCs in the primo nodes and confirmed the hypothesis. The MCs were uniformly distributed in the nodes. The relative concentration of the MCs with respect to other cells was ∼15%. We divided the sizes of the primo nodes into three classes: large, medium, and small. The number density and the relative concentration of MCs did not show a size-dependence. The current work suggests that the PVS may participate in the immune response to allergic inflammation, which closely involves MCs.
肥大细胞（MCs）在过敏反应中起主要作用。令人惊讶的是，与皮肤中的非穴位相比，穴位处的肥大细胞密度更高，这与针刺治疗增强免疫功能相一致。我们推测，作为穴位和经络解剖结构而被提出的原血管系统（PVS）应该具有高密度的肥大细胞。为了验证这一假设，我们研究了从肝脏、小肠、大肠和膀胱等内脏表面分离出的原结。收获的原结用甲苯胺蓝染色，肥大细胞通过其红紫色染色和特征性颗粒很容易被识别。结果显示原结中肥大细胞密度很高，证实了这一假设。肥大细胞在结中均匀分布。肥大细胞相对于其他细胞的相对浓度约为15%。我们将原结的大小分为三类：大、中、小。肥大细胞的数量密度和相对浓度没有显示出大小依赖性。目前的研究表明，原血管系统可能参与了与肥大细胞密切相关的过敏性炎症免疫反应。
