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全身注射后功能化碳纳米管在小鼠脑中的分布动力学：从空间到超微结构分析

Kinetics of functionalised carbon nanotube distribution in mouse brain after systemic injection: Spatial to ultra-structural analyses.

作者信息

Wang Julie T-W, Rubio Noelia, Kafa Houmam, Venturelli Enrica, Fabbro Chiara, Ménard-Moyon Cécilia, Da Ros Tatiana, Sosabowski Jane K, Lawson Alastair D, Robinson Martyn K, Prato Maurizio, Bianco Alberto, Festy Frederic, Preston Jane E, Kostarelos Kostas, Al-Jamal Khuloud T

机构信息

Institute of Pharmaceutical Science, Faculty of Life Sciences & Medicine, King's College London, London SE1 9NH, UK.

CNRS, Institut de Biologie Moléculaire et Cellulaire, Laboratoire d'Immunopathologie et Chimie Thérapeutique, Strasbourg F-67000, France.

出版信息

J Control Release. 2016 Feb 28;224:22-32. doi: 10.1016/j.jconrel.2015.12.039. Epub 2015 Dec 30.

DOI:10.1016/j.jconrel.2015.12.039
PMID:26742944
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4756275/
Abstract

Earlier studies proved the success of using chemically functionalised multi-walled carbon nanotubes (f-MWNTs) as nanocarriers to the brain. Little insight into the kinetics of brain distribution of f-MWNTs in vivo has been reported. This study employed a wide range of qualitative and quantitative techniques with the aim of shedding the light on f-MWNT's brain distribution following intravenous injection. γ-Scintigraphy quantified the uptake of studied radiolabelled f-MWNT in the whole brain parenchyma and capillaries while 3D-single photon emission computed tomography/computed tomography imaging and autoradiography illustrated spatial distribution within various brain regions. Raman and multiphoton luminescence together with transmission electron microscopy confirmed the presence of intact f-MWNT in mouse brain, in a label-free manner. The results evidenced the presence of f-MWNT in mice brain parenchyma, in addition to brain endothelium. Such information on the rate and extent of regional and cellular brain distribution is needed before further implementation into neurological therapeutics can be made.

摘要

早期研究证明，使用化学功能化多壁碳纳米管（f-MWNTs）作为大脑的纳米载体是成功的。关于f-MWNTs在体内大脑分布动力学的见解报道较少。本研究采用了广泛的定性和定量技术，旨在揭示静脉注射后f-MWNTs在大脑中的分布情况。γ闪烁扫描法定量了研究的放射性标记f-MWNT在全脑实质和毛细血管中的摄取量，而三维单光子发射计算机断层扫描/计算机断层扫描成像和放射自显影则显示了不同脑区的空间分布。拉曼光谱和多光子发光以及透射电子显微镜以无标记的方式证实了小鼠大脑中完整f-MWNT的存在。结果证明，除了脑内皮之外，小鼠脑实质中也存在f-MWNT。在进一步应用于神经治疗之前，需要了解有关区域和细胞大脑分布的速率和范围的此类信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a33/4756275/72564098a9d8/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a33/4756275/2bd79e84775f/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a33/4756275/2acbb4ba7430/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a33/4756275/577fce0abc17/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a33/4756275/095f566a44fb/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a33/4756275/60e61caf3aef/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a33/4756275/6bf187c7f1db/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a33/4756275/72564098a9d8/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a33/4756275/2bd79e84775f/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a33/4756275/2acbb4ba7430/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a33/4756275/577fce0abc17/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a33/4756275/095f566a44fb/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a33/4756275/60e61caf3aef/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a33/4756275/6bf187c7f1db/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a33/4756275/72564098a9d8/gr6.jpg

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