EBER在儿童癌症中的预后作用。
The prognostic role of EBER in pediatric cancer.
作者信息
Căinap Simona Sorana, Fetică Bogdan, Buiga Rareş, Căinap Călin, Constantin Anne-Marie, Şovrea Alina Simona
机构信息
Department of Medical Oncology, "Prof. Dr. Ion Chiricuta" Oncological Institute, Cluj-Napoca, Romania;
出版信息
Rom J Morphol Embryol. 2015;56(4):1269-77.
The Epstein-Barr virus (EBV) infection is an endemic disease, over 90% of the population being exposed to it by adulthood. EBV is implicated in the etiology of a significant number of neoplasms, which acquire particular features in terms of course and prognosis. Incidence rates are much higher in children. To establish the link between EBV and neoplasms, EBER (Epstein-Barr virus non-encoded RNAs) needs to be highlighted in tumor tissue. The role of EBV in patient response to oncological treatment remains controversial.
爱泼斯坦-巴尔病毒（EBV）感染是一种地方性疾病，超过90%的人口在成年前就已接触过该病毒。EBV与大量肿瘤的病因有关，这些肿瘤在病程和预后方面具有特殊特征。儿童的发病率要高得多。为了建立EBV与肿瘤之间的联系，需要在肿瘤组织中突出显示EBER（爱泼斯坦-巴尔病毒非编码RNA）。EBV在患者对肿瘤治疗的反应中的作用仍存在争议。
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