Zapf J, Feuerlein D, Waldvogel M, Froesch E R
Diabetologia. 1975 Dec;11(6):509-16. doi: 10.1007/BF01222100.
Adipose tissue from streptozotocin-diabetic rats exhibits half-maximal lipolytic responses (FFA, glycerol release, increase in tissue FFA) to epinephrine at hormone concentrations 5-10 times lowere than those required for half-maximal stimulation of lipolysis in adipose tissue from normal rats. The lipolytic response to epinephrine also occurs more promptly and the antilipolytic effect of insulin in the presence of submaximal epinephrine conceptrations is much less pronounced than in normal tissue. In contrast, diabetic adipose tissue is less responsive to ACTH and glucagon than normal tissue. Half-maximal lipolytic responses are elicited by similar dibutyryl cyclic AMP concentrations in both tissues. Insulin treatment of diabetic rats during 24 hrs restores the lipolytic response of their adipose tissue to epinephrine to nearly normal. Our findings point to an abnormality of diabetic adipose tissue possibly related to the hypersensitivity of catecholamines encountered in denervated organs which are adrenergically innvervated. They are consistent with present concept of different hormone discriminators on the fat cell membrane and offer a further explanation for increased FFA mobilization in the diabetic state.
链脲佐菌素诱导的糖尿病大鼠的脂肪组织，对肾上腺素产生半数最大脂解反应（游离脂肪酸、甘油释放、组织游离脂肪酸增加）时所需的激素浓度，比正常大鼠脂肪组织产生半数最大脂解刺激所需浓度低5至10倍。对肾上腺素的脂解反应也出现得更快，并且在肾上腺素亚最大浓度存在时，胰岛素的抗脂解作用比正常组织中要弱得多。相比之下，糖尿病脂肪组织对促肾上腺皮质激素和胰高血糖素的反应比正常组织弱。两种组织中，类似的二丁酰环磷酸腺苷浓度均可引发半数最大脂解反应。对糖尿病大鼠进行24小时胰岛素治疗，可使其脂肪组织对肾上腺素的脂解反应恢复到接近正常水平。我们的研究结果表明，糖尿病脂肪组织存在异常，这可能与去神经支配器官（这些器官接受肾上腺素能神经支配）中遇到的儿茶酚胺超敏反应有关。它们与目前关于脂肪细胞膜上不同激素识别器的概念一致，并为糖尿病状态下游离脂肪酸动员增加提供了进一步的解释。
