McAnearney Shane, Drain Maire
Department of Medicine, Daisy Hill Hospital, Newry, Northern Ireland, UK.
Respir Med Case Rep. 2015 Apr 30;16:7-10. doi: 10.1016/j.rmcr.2015.04.006. eCollection 2015.
Pulmonary tumour thrombotic microangiopathy (PTTM) is a rapidly progressive pulmonary disease that is a fatal complication of malignancy. It manifests clinically as subacute respiratory failure with pulmonary hypertension, progressive right sided heart failure, and sudden death. We describe here a case of PTTM associated with occult metastatic signet ring cell carcinoma of the stomach. Although rare, PTTM needs to be considered in the differential diagnosis of dyspnoea of unknown origin, particularly in patients with respiratory failure and also pulmonary hypertension, and in patients were there is no improvement in respiratory symptoms with steroid therapy.
肺肿瘤血栓性微血管病（PTTM）是一种迅速进展的肺部疾病，是恶性肿瘤的致命并发症。其临床特征为伴有肺动脉高压的亚急性呼吸衰竭、进行性右心衰竭和猝死。我们在此描述一例与隐匿性转移性胃印戒细胞癌相关的PTTM病例。尽管罕见，但在不明原因呼吸困难的鉴别诊断中，尤其是在患有呼吸衰竭和肺动脉高压的患者以及使用类固醇治疗后呼吸症状无改善的患者中，需要考虑PTTM。
