Hara Naofumi, Fujimoto Nobukazu, Miyamoto Yosuke, Yamagishi Tomoko, Asano Michiko, Fuchimoto Yasuko, Wada Sae, Ozaki Shinji, Kishimoto Takumi
Department of Respiratory Medicine, Okayama Rosai Hospital, Okayama, Japan.
Department of Medical Oncology, Okayama Rosai Hospital, Okayama, Japan.
Respir Med Case Rep. 2015 Nov 23;16:169-71. doi: 10.1016/j.rmcr.2015.11.002. eCollection 2015.
Primary effusion lymphoma (PEL) is a subtype of non-Hodgkin lymphoma that presents as serous effusions without detectable masses or organomegaly. Here we report a case of PEL-like lymphoma in a patient with past asbestos exposure. A 65-year-old man was referred to our hospital due to dyspnea upon exertion. He had been exposed to asbestos for three years in the construction industry. Chest X-ray and CT images demonstrated left pleural effusion. Cytological analysis of the pleural effusion revealed large atypical lymphocytes with distinct nuclear bodies and high nucleus-to-cytoplasm ratio. Immunohistochemical analyses showed that the cells were CD20(+), CD3(-), CD5(-), and CD10(-). These findings led to a diagnosis of diffuse large B-cell lymphoma. PEL or PEL-like lymphoma should be considered a potential cause of pleural effusion in subjects with past asbestos exposure.
原发性渗出性淋巴瘤（PEL）是非霍奇金淋巴瘤的一种亚型，表现为浆液性渗出液，无可检测到的肿块或器官肿大。在此，我们报告一例既往有石棉接触史患者的PEL样淋巴瘤病例。一名65岁男性因劳力性呼吸困难转诊至我院。他曾在建筑行业接触石棉三年。胸部X线和CT图像显示左侧胸腔积液。胸腔积液的细胞学分析显示有大的非典型淋巴细胞，具有明显的核体和高核质比。免疫组化分析显示细胞CD20(+)、CD3(-)、CD5(-)和CD10(-)。这些发现导致诊断为弥漫性大B细胞淋巴瘤。对于既往有石棉接触史的患者，应考虑PEL或PEL样淋巴瘤是胸腔积液的潜在原因。
