Shanghai Key Laboratory of Intelligent Manufacturing and Robotics, School of Mechatronics Engineering and Automation, Shanghai University, Shanghai, People's Republic of China, 200444.
Biofabrication. 2016 Jan 8;8(1):015005. doi: 10.1088/1758-5090/8/1/015005.
Calcium phosphate (CaP) materials have been proven to be efficacious as bone scaffold materials, but are difficult to fabricate into complex architectures because of the high processing temperatures required. In contrast, polymeric materials are easily formed into scaffolds with near-net-shape forms of patient-specific defects and with domains of different materials; however, they have reduced load-bearing capacity compared to CaPs. To preserve the merits of CaP scaffolds and enable advanced scaffold manufacturing, this manuscript describes an additive manufacturing process that is coupled with a mold support for overhanging features; we demonstrate that this process enables the fabrication of CaP scaffolds that have both complex, near-net-shape contours and distinct domains with different microstructures. First, we use a set of canonical structures to study the manufacture of complex contours and distinct regions of different material domains within a mold. We then apply these capabilities to the fabrication of a scaffold that is designed for a 5 cm orbital socket defect. This scaffold has complex external contours, interconnected porosity on the order of 300 μm throughout, and two distinct domains of different material microstructures.
钙磷（CaP）材料已被证明是有效的骨支架材料，但由于需要较高的加工温度，难以制成复杂的结构。相比之下，聚合物材料很容易被制成具有接近净形状的患者特定缺陷和不同材料域的支架；然而，与 CaP 相比，它们的承载能力降低。为了保留 CaP 支架的优点并实现先进的支架制造，本文描述了一种与模具支撑结合使用的增材制造工艺，用于悬空特征；我们证明，该工艺能够制造具有复杂、接近净形状轮廓和不同微结构的不同域的 CaP 支架。首先，我们使用一组典型结构来研究在模具内制造复杂轮廓和不同材料域的不同区域。然后，我们将这些能力应用于制造一种设计用于 5 厘米眼眶窝缺陷的支架。该支架具有复杂的外部轮廓，整个支架的连通孔隙率约为 300μm，并且具有两种不同材料微结构的两个不同域。
